摘要
Abstract
Objective To evaluate the effect of dezocine 1 0 mg for reducing emergence agitation after general anesthesia in patients undergoing laparoscopic cholecystectomy. Methods Sixty patients scheduled for laparoscopic cholecystectomy were randomly divided into dezocine group(n=30)and control group(n=30).Anesthesia was equally maintained with sevoflurane,propofol,fentanyl and atracurium in both groups. Dezo-cine group received intravenous injection of 1 0 mg dezocine at the beginning of the operation,while control group received intravenous injection of 2 ml normal saline. Riker sedation-agitation scale (SAS)was recorded at eye-opening,extubation,1 5 min,30 min,1 h,2 h and 4 h after extubation,respectively,while VAS was recorded at 1 5 min,30 min,1 h,2 h and 4 h after extubation,respectively. Dosage of fentanyl,awakened time,extubation time and frequency of nausea and vomiting in 6 hours after operation were recorded. The re-sults of two group were compared. Results Compared with control group,SAS and VAS were lower in dezo-cine group at all time points (P<0.01 ),and the dosage of fentanyl was also lower in dezocine group (P<0.01 ). No differences were found within awakened time,extubation time and the frequency of nausea and vom-iting in 6 h after the operation among two groups (P>0.05 ). Conclusion Intravenous injection of 1 0 mg dezocine at the beginning of operation can reduce emergence agitation and postoperative pain in patients under-going laparoscopic cholecystectomy,as well as reduce the demand of intraoperative opioid.关键词
地佐辛/全身麻醉/苏醒期躁动/腹腔镜胆囊切除术Key words
Dezocine/General anesthesi/Emergence agitation/Laparoscopic cholecystectomy
