摘要
Abstract
Objective To investigate the role of serum cystatin C for prediction of cardiovascular events .Methods This study included 67 end stage renal disease patients .The following laboratory data were obtained:cystatin C, creatinine, blood urea nitrogen (BUN), lipid profile, hemoglobin, albumin and C reactive protein (CRP) levels were measured at the point of enrollment.Results Cystatin C and blood BUN ( r =0.527, P <0.05), SCr ( r =0.491, P <0.05) were posi-tively correlated.With age ( r =-0.326, P =0.05), eGFR ( r =-0.499, P <0.005) were negatively correlated.Cardi-ovascular events, Kaplan Meier survival analysis showed that the Cys C levels (≥3.14 mg/L) group have a higher event-free survival rate than Cys C levels relatively low (<3.14 mg/L) group ( P =0.028).In univariate analysis, Cys C can effec-tively predict the occurrence of cardiovascular events (OR =2.622, 95%CI 1.241-5.518, P =0.010).Conclusion Serum Cys C could become an independent marker for ESRD patients with cardiovascular events .It may become a new factor to predict cardiovascular events .关键词
心血管疾病/胱抑素C/终末期肾病/肾小球滤过率Key words
Cardiovascular disease/Cystatin C/End stage renal disease/Glomerular filtration rate
