摘要
Abstract
Objective To evaluate the efficacy and safety of combination therapy of aspirin and dipyridamole in sec-ondary prevention of ischemia stroke.Methods Retrieval PUBMED, Cochrane Database of Systematic Reviews , EMBASE, CNKI, found articles about conducted randomized controlled trials of combination of aspirin and dipyridamole in the secondary prevention of stroke , while the included literature references were screened according to inclusion rigorous screening and exclu -sion criteria, the study met the inclusion criteria for the use of Revman 5.0 Meta-analysis software.Results A total of five sub-standard RCT , including 8 619 patients with cerebral infarction or TIA , treated group ( combination of aspirin and dipyri-damole) of 4 315 patients, 4 304 cases in the control group (aspirin alone).Meta-analysis showed that: the combination of aspirin and dipyridamole conduct secondary prevention of stroke compared with aspirin alone , significantly reduces the recur-rence rate of stroke (OR =0.84, 95% CI 0.73-0.97, P =0.02) and lack of blood event rate (OR=0.80, 95% CI 0.69-0.92, P =0.002), whereas the incidence of major bleeding (OR =0.91, 95% CI 0.73-1.14, P =0.41) and mortality (OR =0.90, 95%CI 0.78-1.04, P =0.16) showed no significant difference .Conclusion Compared with as-pirin alone , the combination of aspirin and dipyridamole conduct secondary prevention of stroke , can significantly reduce the recurrence rate of stroke and the incidence of ischemic events without increasing the incidence of bleeding and mortality .关键词
卒中,缺血性/阿司匹林/双嘧达莫/二级预防/Meta分析Key words
Cerebral stroke ,ischemic/Aspirin/Dipyridamole/Secondary prevention/Meta-analysis
