张绿明 1韩国庆 2杨旭 3徐依成 1李继来 1杜继臣1
作者信息
- 1. 100049 北京，航天中心医院 北京大学航天临床医学院 神经内科
- 2. 100853 北京，解放军总医院神经外科
- 3. 南开大学医学院
- 折叠
摘要
Abstract
Objective To investigate the clinical features, radiological and pathological features of gliomatosis cere -bri, in order to improve the diagnosis and treatment .Methods From July 2007 to October 2013, a retrospective analysis of the clinical data of admitted pathological diagnosed brain glioma patients (10 cases) was performed.Results In the 10 pa-tients, there were 6 males and 4 females, aged from 28 to 75 years old, median 47.4 years of age, combined with increased intracranial pressure, neurological deficits or irritating symptoms onset , skull imaging examination showed diffuse lesions , in-volving ≥ 3 cerebral lobes.Cranial CT scan showed low density , head MR scan showed slightly lower signal on T 1WI, T2WI and FLAIR showed high signal, enhancement scan showed no enhancement or only mild enhancement .All 10 patients were pathologically confirmed, five cases in line with WHO II-grade III,4 patients in grade II,1 case of grade III.Pathological ex-amination showed abnormal proliferation of glial cells with mild nuclear shaped , seven cases with diffuse astrocyte -based, two cases with diffuse mainly oligodendrocytes , one case was astrocytes hyperplasia concomitant oligodendrocyte proliferation , re-vealed "structural growth".Immunohistochemical staining showed GFAP ( +or + +), in some cases Olig-2 (-or +) P53 showed between 5% -75% ( +) except the main types are oligodendrocyte proliferation , Ki 67 in 5% to 50% ( +).Six cases underwent surgery, one case was lost of follow up, rest five cases were survived at the end of follow up ; in the 4 cases of non-surgical patients, 2 patients died, survived of two cases.Conclusion Gliomatosis cerebri has low incidence .The clin-ical manifestations are not specific, imaging and pathological examination showed characteristic changes , combined with ima-ging and pathological findings can improve the accuracy of diagnosis , operation excision of the lesion may prolong the survival time than non-operation treatment.关键词
大脑胶质瘤病/临床特点/影像学/病理学/预后Key words
Gliomatosis cerebri/Clinical features/Imaging/Pathology/Prognosis
