摘要
Abstract
Objective To evaluate the efficacy and safety of perindopril combined with amlodipine or hydrochlorothia -zide in elderly hypertensive patients ,observe its infcuence on serum potassium ,Cystatin and uric acid .Methods Selected 60 cases of elderly hypertensive patients , they were randomly divided into two groups , given perindopril +amlodipine ( amlodip-ine group, n =30) or perindopril +hydrochlorothiazide (HCTZ group, n =30) antihypertensive treatment respectively , ob-served 24 h ambulatory blood pressure , detect serum potassium , serum cystatin and blood uric acid levels before and after treatment begin and eight weeks after treatment .Results Compared with before treatment , amlodipine and hydrochlorothiazide in blood pressure indicators were lower ( except hydrochlorothiazide group dDBP ) , and the former reduced rate significantly higher than the latter( P <0.05).After treatment, the amlodipine group was higher than standard blood pressure hydrochlo-rothiazide group (90.0%vs.76.7%, P <0.05).2 group antihypertensive drugs trough to peak ratios were greater than 50%, systolic blood pressure amlodipine group trough to peak ratio ( SBPT/P) is greater than the hydrochlorothiazide group (P <0.05), diastolic blood pressure trough to peak ratio (DBPT /P) is slightly larger than hydrochlorothiazide group , the difference was not statistically significant ( P >0.05).Compared with before treatment , after treatment, the two groups had improved blood pressure smoothness index ( P <0.05), and the amlodipine group than hydrochlorothiazide group ( P <0.05).After amlodipine treatment cystatin levels were significantly lower ( P <0.05), hydrochlorothiazide group also de-creased, but the difference was not statistically significant ( P >0.05).Uric acid levels in the two groups had no significant change in serum potassium ( P >0.05).Conclusion Perindopril and amlodipine or hydrochlorothiazide can significantly re-duce blood pressure in elderly hypertensive patients , but the former has better antihypertensive effect than the latter .Perindopril amlodipine acid in smoothness index raise blood pressure , improve blood pressure circadian rhythm , stable blood pressure , kidney and other aspects of the role of stronger protection may be more suitable for elderly patients with hypertension .关键词
高血压病/培哚普利/氨氯地平/氢氯噻嗪/动态血压/胱抑素/尿酸/老年人Key words
Hypertension/Perindopril/Amlodipine/Hydrochlorothiazide/Ambulatary blood pressure/Cystatin/Uric acid/Elderly
