医学信息Issue(21)：56-57,2.
新诊断2型糖尿病患者骨骼肌胰岛素抵抗的定量研究
Study on Insulin Resistance of Skeletal Muscle in Patients with Newly Diagnosed Type 2 Diabetes Mellitus
摘要
Abstract
Objective:To investigate the feature of insulin resistance, especial y insulin resistance of skeletal muscle, in Patients with Newly Diagnosed Type 2 Diabetes Mel itus. Methods:48 patients with newly diagnosed T2DM were enrol ed as T2DM group and another 20 participants with NGT were recruited as control group.Glycemic control, lipid profile, HOMA indices, and IMCL quantified by 1H-magnetic resonance spectroscopy were tested and compared.Results:In T2DM group, the HOMA-IR and IMCL in soleus and tibilis anterior muscles were higher than those in control group (P<0.05).The correlation analyses showed that IMCL was positively correlated to HOMA-IR, but not with BMI, waist to hip ratio and lipid profile. Conclusion:Insulin resistance exists in the skeletal muscle of patients with newly diagnosed T2DM. IMCL is a credible tissue marker for skeletal muscle insulin resistance, independent of obesity and lipid profile.关键词
2型糖尿病/胰岛素抵抗/骨骼肌肌纤维细胞内脂肪含量Key words
Type 2diabetes mel itus/Insulin resistance/Skeletal muscle fiber intracellular fat content引用本文复制引用
万学思,马玲,廖义清,黄知敏,李延兵..新诊断2型糖尿病患者骨骼肌胰岛素抵抗的定量研究[J].医学信息,2013,(21):56-57,2.基金项目
不同治疗方式对2型糖尿病大鼠胰岛β细胞功能保护及缓解病情作用的对比研究项目 （）
