医学信息Issue(25)：80-81,2.
产超广谱β-内酰胺酶革兰阴性杆菌的检测和耐药性研究
Detection of ESBL-producing Clinical Isolates of Gram Negative Bacilli and their Antibiotic Resistance
于瑞荣 1陈伟 1秦明 1张晓丽1
作者信息
- 1. 济南市平阴县孝直中心卫生院，山东 济南 250402
- 折叠
摘要
Abstract
Objective To evaluate the extended-spectrum beta-lactamases (ESBLs) producing clinical isolates of gram negative bacil i and their antibiotic resistance and to provide suggestions on empirical treatment against the bacteria. Methods examined for the production of ESBLs by Vitek-32 and antibacterial susceptibility was tested by Kindy Bauer method. Results:Among a total of 317 Gram negative isolates,There were most of escherichia coli (E.coli)and klebsiel a pneumoniae (K.pneumoniae) producing ESBLs. To examined for the production of ESBLs and antibacterial susceptibility test,the drug resistance rate of ESBLs producing strains was much higher than that of strains no producing ESBLs to 15 types antibiotics. Conclusions:Along with antibiotics widespread application,The resistance rate of the ESBLs-producing strains to penicil ins、cephalosporins and monocyclic beta-lactam antibiotics were very high.The ESBLs-producing strains were multidrug resistant,but both of them were stil highly sensitive to carbopenems and these β-lactamase inhibitor combmations.Now,Drug resistance became more and more serious,which suggested clinical treatment should choose the antibiotics according to susceptiblity tests and detection for ESBLs producing strains and provide the reference for the clinical antibiotics usage.关键词
革兰阴性杆菌/产超广谱β-内酰胺酶/耐药性Key words
Gram negative bacteria/Extended-spectrumβ-lactamases/Antibiotic resistance引用本文复制引用
于瑞荣,陈伟,秦明,张晓丽..产超广谱β-内酰胺酶革兰阴性杆菌的检测和耐药性研究[J].医学信息,2013,(25):80-81,2.
