摘要
Abstract
Objective To study the correlation of biological markers P53、Ki-67expression in breast cancer with the ef ect of neoadjuvant chemotherapy (NAC).To search predictive factors of NAC. Methods From Jun 2008 to Dec 2012,49 breast cancer patients in our hospital with NAC were enrol ed in the sthdy.The expressions of P53、Ki-67 were detected by immunohistochemical method before NAC. Reponse rate was evaluated after 2~6 cycles of NAC.The correlation between expressions of biomarkers and the ef ect of NAC were analyzed. Results Among the 49 cases of NAC,the positive expression rate of P53、Ki-67 was 52.2%、39.1%,respectively. The clinical reponse rate (RR)was 79.6%,with clinical completed response (cCR)34.7%,clinical partial reponse (cPR)44.9%,stable disease (SD)18.4%,progressive disease (PD)2.0%,pathologic complete reponse(pCR)10.2%. Conclusion:In the breast cancer patients,P53 negative and Ki-67 positive tunors are more sensitive to NAC.P53、Ki-67 can be considered as predictive markers of the ef ect of NAC.关键词
乳腺癌/新辅助化疗/P53/Ki-67Key words
Breast cancer/Neoadjuvant chemotherapy/P53/Ki-67
