摘要
Abstract
Objective to explore the best anesthesia dosages of sodium pentobarbital and improvement of bilateral oophorectomy through application of l0-week-old ICR mice during preoperative period. Methods ICR strains female mice in SPF of 6 weeks-age were selected for 60, randomly divided into normal group and hepatic injury group. The normal group fed a standard diets while liver injury group fed choline methionine deficient diets (Methionine and choline deficient diets, MCD diets). After 4 weeks, the mice were injected with 1% sodium pentobarbital by intraperitoneal injection. The dose was 80mg/kg and 10mg/kg respectively. The anesthetic ef ects and postoperative recovery were observed. The improved measures of insulation and coating with antibiotics in the wound to prevent infection and other measures were taken to explore the mice improved bilateral ovaries cut surgery during perioperative period. Results 1% sodium pentobarbital with 80mg/kg and 10mg/kg could ensure a safe and ef ective anesthetic. The improved measures of warming and coating with antibiotics in the wound to prevent infection and other measures were taken during and after operation, which can promote recovery and augment survival rate. Conclusion Doses of sodium pentobarbital used were dif erent in the physiological and pathological conditions, especial y in liver injury, the doses should be greatly reduced and used modestly. The methods of insulation and prevention of infection and etc. improved the bilateral ovaries cut surgery during perioperative period, accelerating the postoperative recovery, improving the survival rate and reducing the postoperative complications.关键词
戊巴比妥钠/麻醉/肝损/卵巢切除术/围手术期Key words
Sodium pentobarbital/Anesthesia/Liver damage/Oophorectomy/Perioperative period分类
医药卫生
