中国肺癌杂志Issue(11)：591-595,5.DOI:10.3779/j.issn.1009-3419.2013.11.05
干细胞转录因子Sox2在肺癌中的表达和意义
The Expression and Signiifcance of Stem Cell Transcription Factor Sox2 in Lung Carcinoma
摘要
Abstract
Background and objective Transcription factor Sox2 remains the pluripotency of stem cell, partici-pates in self-renew of cancer stem cell and plays important role during the initiation and development of various cancers. hTis study intends to investigate the expression and signiifcance of Sox2 and Sox2 autoantibodies (Sox2-Ab) in tissue and serum of patients with non-small cell lung cancer (NSCLC). Methods Expression of Sox2 gene and protein was tested in 58 cases of NSCLC, 16 patients with other tumors and 20 cases of normal lung tissue specimens by quantitative PCR and immunohis-tochemical assay, respectively. Serum Sox2-Ab level was detected in 30 cases of NSCLC patients and 30 healthy controls by ELISA method. Clinical and pathological data from patients were collected and analyzed retrospectively. Results Expression levels of Sox2 mRNA and protein were higher in patient with NSCLC than other groups, with statistically signiifcant differenc-es (P<0.01), respectively. Meanwhile, Sox2 mRNA expression increased in NSCLC patients associated with histological type and tumor size. No signiifcant differences in Sox2-Ab serum levels were found between NSCLC patients and normal subjects. Conclusion Sox2 in NSCLC have a higher expression, which is closely related to histological type and tumor size. Sox2 might use as a potential biomarker and therapeutic target for lung cancer.关键词
肺肿瘤/Sox2/Sox2自身抗体/肿瘤干细胞Key words
Lung neoplasms/Sox2/Sox2 self-antibody/Cancer stem cells引用本文复制引用
许伟,位云艳,谭瑶曦,徐玮,程雁,吴剑卿..干细胞转录因子Sox2在肺癌中的表达和意义[J].中国肺癌杂志,2013,(11):591-595,5.基金项目
本研究受国家自然科学基金资助项目（No.30971320, No.81272602, No.81302014）、江苏省高校自然科学研究项目资助（No.12KJB320004）、江苏省干部保健科研课题（No.019）和江苏高校优势学科建设工程资助项目资助 （）
