摘要
Abstract
Lung cancer is severely threatening human health. In recent years, the treatment for lung adenocarci-noma has made a great progress, targeted therapy has been widely applied in clinic, and beneifts amount of patients. However, in squamous cell lung cancer, the incidence of epidermal growth factor receptor (EGFR) gene mutant and ALK fusion gene are low,and targeted therapy like Tarceva and crizotinib, can hardly work. Since the ifbroblast growth factors (ifbroblast growth fac-tor, FGF) pathway is considered to be related to tumor cell proliferation, metastasis and angiogenesis, more and more research-es proved the ampliifcation of ifbroblast growth factor receptor (FGFR) in squamous cell lung cancer. Experiments in vivo and in vitro found that blocking FGF pathway could reduce the proliferation of tumor cells and inhibit metastasis. hTe FGF pathway might be a new target for treatment of squamous cell lung cancer. hTis article reviews the effect of FGFR in tumorigenesis,as well as the prospect as a therapeutic target in non-small cell lung cancer.关键词
非小细胞肺癌/成纤维生长因子受体/表皮生长因子受体/抗血管生成治疗Key words
Lung neoplsms/Fibroblast growth factor receptor/Epidermal growth factor receptor/Anti-angiogene-sis treatment
