中国肺癌杂志Issue(12)：632-638,7.DOI:10.3779/j.issn.1009-3419.2013.12.03
BIM基因多态性与复治晚期非小细胞肺癌EGFR-TKI治疗疗效的关系
Relationship Between BIM Gene Polymorphism and Therapeutic Efficacy in the Retreatment of Advanced Non-small Cell Lung Cancer with Tyrosine Kinase Inhibitor
摘要
Abstract
Background and objective BIM gene is a member of the BCL-2 family, is involved in cell death. The aim of this study is to explore the relationship between BIM gene polymorphism and therapeutic efficacy in the retreatment advanced non-small cell lung cancer (NSCLC) with tyrosine kinase inhibitor (EGFR-TKI). Methods In the study, there were 123 patients who were diagnosed with advanced NSCLC in Zhejiang Province Cancer Hospital bewteen January 2009 to October 2012, all of who were received gefitinib and erlotinib therapy after failure to chemotherapy. We detected the genotype of peripheral blood leukocytes of patients with BIM gene polymorphism though polymerase chain reaction (PCR). Statistical analysis was performed by SPSS version 13.0. Results On the disease control rates, BIM gene with no polymorphism type was slightly better trend than polymorphism types in disease control rate DCR (75.5% vs 57.1%, χ2=2.931, P=0.087). Univariate analysis the median PFS, women were longer than men (6.9 months vs 4.5 months, χ2 =7.077, P=0.008). Non-smokers were longer than smokers (8.0 months vs 2.5 months, χ2 =15.277, P<0.001). Adenocarcinoma were longer than others pathological type (7.0 months vs 2.0 months, χ2 =14.978, P<0.001). The median PFS in BIM gene with no polymorphism type were longer than with polymorphism type (6.0 months vs 3.5 months, χ2=7.035, P=0.008). Multi-factor analysis showed that smoking, pathological type, the BIM gene polymorphism were the independent prognostic factors for PFS. Conclusion The patients with the BIM gene no polymorphism have longer the median progression-free time than the polymorphism types in retreatment advanced non-small cell lung cancer patients with tyrosine kinase inhibitor.关键词
BIM基因/多态性/肺肿瘤/酪氨酸激酶抑制剂Key words
BIM Gene/Polymorphism/Lung neoplasms/Tyrosine Kinase Inhibitor引用本文复制引用
郑蕾,林宝钗,宋正波,谢发君,洪卫,冯建国,邵岚,张沂平..BIM基因多态性与复治晚期非小细胞肺癌EGFR-TKI治疗疗效的关系[J].中国肺癌杂志,2013,(12):632-638,7.基金项目
本研究受浙江省自然基金（No.LY13H160024）、卫生部医药卫生科技发展研究中心课题（No.W2012FZ134）和吴阶平研究课题（No.320.6799.1106）资助@@@@This study was supported by a grant from the Zhejiang Province Natural Science Foundation (No. LY13H160024), the Research Subject of Research Center of the Ministry of Health Medical Technology Development (No.W2012FZ134) and Wujieping Medical Foudation (All to Yiping ZHANG)(No.320.6799.1106) （No. LY13H160024）
