中国肺癌杂志Issue(3)：233-237,5.DOI:10.3779/j.issn.1009-3419.2014.03.09
FHIT基因启动子甲基化与肺癌相关性的meta分析
The Relationship between FHIT Gene Promoter Methylation and Lung Cancer Risk:a Meta-analysis
孙义长1
作者信息
- 1. 473058南阳，南阳医学高等专科学校第一附属医院肿瘤内科
- 折叠
摘要
Abstract
Background and objective Tumor-suppressor gene promoter DNA methylation in tumor cells is asso-ciated with its reduced expression. FHIT (fragile histindine triad) was one of the important tumor suppressor genes which was found hypermethylated in the promoter region in most of tumors. hTe aim of this study is to evaluate the relationship between FIHT gene promother methylation and lung cancer risk by meta-analysis. Methods By searching Pubmed, CNKI and Wan-fang, the open published articles related to FHIT gene promoter methylation and lung carcinoma risk were collected. hTe odds ratio (OR) and range of FHIT gene of cancer tissue of lung cancer patients compared with normal lung tissue, plasma and the bronchial lavage lfuid were pooled by statistical sotfware Stata 11.0. Results Eleven studies were ifnally included in this meta-analysis. hTe median methylation rate were Pmedian=40.0%(0-68.3%), Pmedian=8.7%(0-35.0%), Pmedian=33.3%(17.1%-38.3%) and Pmedian=35.9%(31.1%-50.8%) in cancer tissue, NLT, BALF and plasm respectively. hTe pooled results showed the methylation rate in tumor tissue was much higer than that of NLT OR=5.82 (95%CI:3.74-9.06, P<0.05), but without statistical signiifcance for BALF OR=1.55 (95%CI:0.89-2.70, P>0.05) and plasma OR=1.41 (95%CI:0.90-2.20, P>0.05). Conclusion Hypermeth-ylation of FHIT gene promoter region was found more frequent in cancer tissue than that of NLT which may demonstrated association between lung cancer risk and FHIT gene promoter methylation.关键词
肺肿瘤/MGMT基因/甲基化/Meta分析Key words
Lung neoplasms/FHIT gene/Methylation/Meta-analysis引用本文复制引用
孙义长..FHIT基因启动子甲基化与肺癌相关性的meta分析[J].中国肺癌杂志,2014,(3):233-237,5.
