局解手术学杂志Issue(1)：36-38,3.DOI:10.11659/jjssx.1672-5042.201401013
犬不停跳冠状动脉搭桥模型的构建
Structure of off-pump coronary artery bypass graft model in dogs
赵亮 1文灿 2孙建森 3吴杨霄 3杨爱军 2张天飞 2李晓辉1
作者信息
- 1. 解放军白求恩国际和平医院胸心外科，河北 石家庄050200
- 2. 第三军医大学卫勤训练基地医学综合教研室，重庆40038
- 3. 第三军医大学基础部人体解剖学教研室，重庆40038
- 折叠
摘要
Abstract
Objective To study the feasibility of model building methods by analyzing the advantages and disadvantages between the two different methods to build off-pump coronary artery bypass graft animal model. Methods Twenty dogs were randomly divided into two groups:brachiocephalic artery group and descending aorta group. Small-caliber heterogeneous vascular vessels were used as bridge vessels. The incision was in the fourth intercostal space of the left chest. Vascular anastomosis was firstly done between the brachiocephalic artery and bridge vessels,or between descending aorta and bridge vessels,prior to coronary vascular and bridge vessels anastomosis. Results The dogs of two groups were not dead during operation. Brachiocephalic artery group and the descending aorta group:aortic vascular anastomosis times were (33.9 ±4.8) min and (29.6 ±3.5) min respectively (P<0.05),coronary vascular anastomosis time were (28.5 ±3.0) min and (28. 1 ± 2. 3) min respectively (P>0. 05). The surgical blood losses of the two groups were (77. 5 ± 16. 2) mL and (66. 5 ± 12. 3) mL re-spectively (P>0. 05). After side clamping descending aorta,femoral blood pressure significantly decreased in descending aorta group,and the two dogs had melena after operation. Conclusion Off-pump coronary artery bypass graft models were both constructed successfully by the two ways. Descending aorta group of femoral artery blood pressure violently fluctuated and had abdominal organs’ ischemia reperfusion in-jury. Though brachiocephalic artery group anastomosis group spent a little longer time,they had stable artery blood pressure during operation. As a result,the way of constructing animal model of brachiocephalic artery group is safer.关键词
不停跳冠状动脉搭桥/犬/动物模型Key words
off-pump coronary artery bypass graft/dogs/animal model分类
医药卫生引用本文复制引用
赵亮,文灿,孙建森,吴杨霄,杨爱军,张天飞,李晓辉..犬不停跳冠状动脉搭桥模型的构建[J].局解手术学杂志,2014,(1):36-38,3.
