中国康复理论与实践Issue(9)：820-823,4.DOI:10.3969/j.issn.1006-9771.2013.09.006
单核细胞趋化蛋白-1在内源性神经干细胞迁移中的作用
Effects of Monocyte Chemoattractant Protein-1 on Migration of Endogenous Neural Stem Cells
摘要
Abstract
Objective To investigate the effects of monocyte chemoattractant protein-1 (MCP-1) on the migration of neural stem cells in vivo. Methods The brain injured rat model was established with cortical micro-injection of lipopolysaccharide in Sprague-Dawley rats. The tissue of brain was immunohistochemistrically stained to detect the expression of MCP-1 and nestin 3 d, 5 d, and 7 d after modeling. Results The expression of MCP-1 increased, and reached a peak 5 d after modeling. The nestin-positive cells was found in the lipopolysaccharide in-jected area 7 d after modeling. Conclusion MCP-1 may induce the endogenous neural stem cells migrate to lipopolysaccharide injection ar-ea in vivo.关键词
脑损伤/神经干细胞/单核细胞趋化蛋白-1/迁移/大鼠Key words
cerebral injury/neural stem cells/monocyte chemoattractant protein-1/migration/rats分类
医药卫生引用本文复制引用
丁鹏,周长胜,戴孝森,陆斌,王崇谦,王伟民,王进昆..单核细胞趋化蛋白-1在内源性神经干细胞迁移中的作用[J].中国康复理论与实践,2013,(9):820-823,4.基金项目
云南省科技厅-昆明医科大学联合专项基金(No.2010CD157)。 （No.2010CD157）
