中国康复理论与实践Issue(10)：922-926,5.DOI:10.3969/j.issn.1006-9771.2013.10.006
三七总皂苷对大鼠脊髓半横断损伤后的神经保护作用
Protective Effect of Panax Notoginseng Saponins in Spinal Cord Hemisection Injured Rats
皮斌 1孙扬 2熊巍 2沈田 2周志扬2
作者信息
- 1. 苏州大学附属第一医院骨科，江苏苏州市215021
- 2. 中南大学湘雅医学院，湖南长沙市410001
- 折叠
摘要
Abstract
Objective To investigate the protective effect and cytosolic phospholipase A2 (cPLA2) associated mechanism of panax no-toginseng saponins (PNS) in spinal cord hemisection injured rats. Methods 55 adult Sprague-Dawley rats were randomly divided into three groups:sham group (n=5), spinal cord injury group (n=25) and PNS group (n=25). The rats were evaluated with BBB score, pathology and immunohistochemistry 1 d, 3 d, 7 d, 14 d and 21 d after intervention. Results Compared to the spinal cord injury group, motor recovery was significantly better in PNS group 3 d, 7 d, 14 d and 21 d after intervention (P<0.05). Nissl staining showed less neuron necrosis and more in-tegrated neural cells in morphology in PNS group 7 d, 14 d and 21 d after intervention. Cytosolic phospholipase A2 (cPLA2) expression was inhabited, and less number of positive cells were found in PNS group 7 d, 14 d and 21 d after intervention. Conclusion PNS can inhibit the expression of cPLA2 after spinal cord injury, which may be one of the mechanisms of its effect on promoting motor recovery.关键词
三七总皂苷/脊髓损伤/胞浆型磷脂酶A2/大鼠Key words
panax notoginseng saponins/spinal cord injury/cytosolic phospholipase A2/rats分类
医药卫生引用本文复制引用
皮斌,孙扬,熊巍,沈田,周志扬..三七总皂苷对大鼠脊髓半横断损伤后的神经保护作用[J].中国康复理论与实践,2013,(10):922-926,5.
