中国康复理论与实践Issue(11)：1001-1005,5.DOI:10.3969/j.issn.1006-9771.2013.11.001
28烷醇对6-羟基多巴胺致帕金森病大鼠的行为学作用及其机制研究
Effects of Octacosanol on Behavioral Impairments and Its Mechanism through Nerve Growth Factor Mediated Pathway in Parkin-sonism Rats Induced with 6-hydroxydopamine
摘要
Abstract
Objective To investigate the effects of octacosanol on the behavioral changes and its potential mechanism in 6-hydroxydopa-mine-induced Parkinsonism rats. Methods 6-hydroxydopamine-induced Parkinsonism rats accepted octacosanol orally in the dosage of 17.5 mg/kg (low dose), 35 mg/kg (medium dose) and 70 mg/kg (high dose) for 2 weeks, and then assessed with rotating test and narrow beam test. The apoptosis cells were counted with TUNEL assay, and the expression of nerve growth factor (NGF), precursor of nerve growth fac-tor (proNGF), as well as their receptors were detected with Western blotting. Results The achievement of behavioral tests significantly im-proved after administration of octacosanol (P<0.05), with the decrease of the apoptotic cells, more expression of NGF and its receptors TrkA, and less expression of caspase-3, proNGF and its receptors p75NTR and sortilin, especially at the dosage of 70 mg/kg (P<0.05). Con-clusion Octacosanol may protect the neurol impairment from 6-hydroxydopamine through NGF mediated pathway to decrease the apoptosis.关键词
帕金森病/神经生长因子/神经生长因子前体/神经保护/凋亡/大鼠Key words
Parkinson's disease/nerve growth factor/precursor of nerve growth factor/neuroprotection/apoptosis/rats分类
医药卫生引用本文复制引用
王涛,乔洪文,刘雁勇,杨楠,纪超,陈彪,左萍萍..28烷醇对6-羟基多巴胺致帕金森病大鼠的行为学作用及其机制研究[J].中国康复理论与实践,2013,(11):1001-1005,5.基金项目
1.国家973基金项目(No.2010CB934002 （）
No.2011CB504101 （）
No.2011CBA00408)；2.国家自然科学基金资助项目(No.81050025)；3.神经变性病教育部重点实验室开放课题(No.2012SJBX01)；4.北京市脑重大疾病重点实验室开放课题(No.2013NZDJ05)。 （No.81050025）
