中国康复理论与实践Issue(1)：30-33,4.DOI:10.3969/j.issn.1006-9771.2014.01.008
GABABR2基因多态性与维吾尔族人高血压的关系
Relationship of Polymorphism of GABABR2 Gene with Hypertension in Uygur of Xinjiang
摘要
Abstract
Objective To investigate the association of the polymorphism of rs3750344 and rs1435252 of G-protein family GABABR2 gene with hypertension in population of Xinjiang Uygur. Methods 785 Uygur subjects were surveyed with the cardiovascular phenotypes. Tagging single nucleotide polymorphisms (tSNPs) of rs3750344 and rs1435252 of GABABR2 gene were typed with Taqman. Linkage dis-equilibrium and haplotype were analysed with Haploview software. Results The frequency of rs1435252 was significantly different (P<0.05) between hypertension group (GG 43.0%, GA 43.6%, AA 13.5%) and normal control group (GG 44.8%, GA 47.6%, AA 7.6%). The subjects with GA/AA genotype significantly increased risk of hypertension (OR=1.38, 95%CI:1.08~1.76). The associations remained signif-icant after control for age and gender (P<0.05). The frequency of rs3750344 was not significantly different (P=0.204), as TT 71.4%, TC 25.2%, CC 3.5%in the hypertension group, and TT 68.5%, TC 29.6%, CC 1.9%in the normal control group. Conclusion The rs1435252 polymorphism A allele of GABABR2 gene is a risk factor for hypertension in the Uyghur population.关键词
GABABR2基因/多态性/高血压/维吾尔族Key words
GABABR2 gene/polymorphism/hypertension/Uyghur分类
医药卫生引用本文复制引用
李响,王静,职庭帆,袁天佑,解端阳,郑丽娟,蒋晓燕..GABABR2基因多态性与维吾尔族人高血压的关系[J].中国康复理论与实践,2014,(1):30-33,4.基金项目
1.国家自然科学基金青年基金(No.81100551)；2.上海市自然科学基金(No.11ZR1438600)。 （No.81100551）
