中国康复理论与实践Issue(1)：34-36,3.DOI:10.3969/j.issn.1006-9771.2014.01.009
神经节苷脂-1与康复训练对缺血缺氧性脑损伤大鼠神经功能的影响
Effect of Ganglioside-1 and Rehabilitation on Recovery of Neurologic Behavior in Rats with Hypoxic-ischemic Brain Damage
王珂 1杨会娟 2马俊 1候梅1
作者信息
- 1. 青岛市妇女儿童医院，山东青岛市266034
- 2. 莒县人民医院儿保科，山东莒县276500
- 折叠
摘要
Abstract
Objective To investigate the effects and the possible mechanism of Ganglioside-1 (GM1) and rehabilitation on neurologic behaviors of rats with hypoxic-ischemic brain damage (HIBD). Methods 48 immature rats developed as model of HIBD were divided into 5 groups: control group, GM1 group, rehabilitation training group (R group), GM1+R group, and sham group. They were evaluated with Climb, Slope and Water Maze Tests. The expressions of activated caspase-3 in neurons were detected with immunohistochemistry. Results The achievement of Climb and Slope Test were significantly different among groups (P<0.001), which ranked as the sham group>GM1+R group>R group>GM1 group>control group (P<0.05). The latency of Water Maze Test was significantly different among groups (P<0.01), which was longer in the control and GM1 groups than in the sham group (P<0.05). The activated caspase-3 expressed in hippocampus and frontal cortex was less in the GM1 and R groups than in the sham group (P<0.05), more in the GM1 group, R group and GM1+R group than in the control group in hippocampus (P<0.05), more in the R group and GM1+R group than in the control group in frontal cortex (P<0.05). The expression of activated caspase-3 in both hippocampus and frontal cortex correlated with the achievement of Climb and Slope Test (P<0.05), but not with the latency of Water Maze Test (P>0.05). Conclusion Rehabilitation training and GM1 are effective on recovery of neu-ral function in rats with HIBD with synergia, which may associated with the activated caspase-3 in terminal synapse.关键词
缺血缺氧性脑损伤/神经节苷脂-1/康复/caspase-3/大鼠Key words
hypoxic-ischemic brain damage/ganglioside-1/rehabilitation/caspase-3/rats分类
医药卫生引用本文复制引用
王珂,杨会娟,马俊,候梅..神经节苷脂-1与康复训练对缺血缺氧性脑损伤大鼠神经功能的影响[J].中国康复理论与实践,2014,(1):34-36,3.
