中国康复理论与实践Issue(3)：233-235,3.DOI:10.3969/j.issn.1006-9771.2014.03.009
红景天对大鼠脑缺血再灌注c-Fos表达及神经细胞凋亡的影响
Effects of Rhodiola on Expression of c-Fos and Neuronal Apoptosis after Cerebral Ischemia/Reperfusion Injury in Rats
摘要
Abstract
Objective To investigate the effect of Rhodiola Rosae P. E on the expression of c-Fos and the apoptosis of neuronal in rat brain after ischemia/reperfusion (I/R) injury. Methods 120 Wistar rats were divided into sham group, model group and intervention group, subgrouped as 3 h, 6 h, 12 h, 24 h, and 48 h. The model and intervention groups underwent middle cerebral artery occlusion, and the latter accepted Rhodiola 0.672 g/kg daily for 15 d. They were assessed with Longa's score. The expression of c-Fos and apoptosis of neuronal were measured with immunohistochemistry and TUNEL. Results The expression of c-Fos in the ischemic area increased after cerebral isch-emia/reperfusion (P<0.01), peaking at 24 h after injury, and decreased in the intervention group (P<0.01), with the decrease of neuron apop-tosis and Longa's score (P<0.01). Conclusion Rhodiola protects the brain tissue against ischemia/reperfusion injury by inhibiting the expres-sion of c-Fos and apoptosis in rats.关键词
红景天/缺血再灌注/c-Fos/神经元/凋亡Key words
Rhodiola/ischemia/reperfusion/c-Fos/neuron/apoptosis分类
医药卫生引用本文复制引用
陈江君,刘宁,陈军..红景天对大鼠脑缺血再灌注c-Fos表达及神经细胞凋亡的影响[J].中国康复理论与实践,2014,(3):233-235,3.基金项目
甘肃省自然科学基金项目(No.1107RJYA072)。 （No.1107RJYA072）
