中国康复理论与实践Issue(3)：240-244,5.DOI:10.3969/j.issn.1006-9771.2014.03.011
以微管相关蛋白Tau为靶点的抗阿尔茨海默病药物研究进展
Advance in Drug Development for Alzheimer's Disease Targeted Microtuble Associated Protein Tau (review)
摘要
Abstract
Alzheimer's disease (AD) is the general neurodegenerative disease in the elderly. Alterations of microtubule associated pro-tein tau are closely related to the onset and progression of AD. The role of tau protein in the development of AD has been a focus in the cur-rent study of AD, with an emphasis on the identification of compounds that inhibit tau protein phosphorylation and aggregate, and accelerate tau protein depolymerization. The current research status of tau protein as target of AD preventive and therapeutic drug was also reviewed.关键词
阿尔茨海默病/神经纤维缠结/微管相关蛋白tau/药物/综述Key words
Alzheimer's disease/neurofibrillary tangles/microtubule associated protein tau/drug/review分类
医药卫生引用本文复制引用
郐学先,于建春,张兰..以微管相关蛋白Tau为靶点的抗阿尔茨海默病药物研究进展[J].中国康复理论与实践,2014,(3):240-244,5.基金项目
1.国家自然科学基金项目(No.81274120)；2.北京市自然科学基金项目(No.7132110)；3.北京市新世纪百千万人才工程项目(No.008-0014)；4.北京市高层次卫生人才工程项目(No.2009-3-66)；5.教育部留学回国人员科研启动基金项目(第45批)。 （No.81274120）
