中国康复理论与实践Issue(4)：347-350,4.DOI:10.3969/j.issn.1006-9771.2014.04.011
超敏C-反应蛋白结合同型半胱氨酸预测急性缺血性脑卒中短期预后
Prediction of Combination of High-sensitivity C-reactive Protein and Homocysteine on Short-term Outcomes of Patients with Acute Ischemic Stroke
摘要
Abstract
Objective To explore the relationship of high-sensitivity C-reactive protein (Hs-CRP), homocysteine (HCY) levels and the short-term outcome of acute ischemic stroke (AIS). Methods 189 patients with AIS were included. Serum Hs-CRP, HCY levels and Nation-al Institute of Health Stroke Scale (NIHSS) were assessed after admission. Short-term functional outcome was measured by modified Rankin Scale (mRS) 90 d after admission. Results The serum Hs-CRP and HCY levels were significantly higher in AIS patients than in nor-mal controls (P<0.001). Adjusting age and the NIHSS score, Hs-CRP and HCY were independent prognostic markers of functional outcome and death in patients with AIS. In receiver operating characteristic curve (ROC) analysis, the prognostic accuracy of combined model (HCY and Hs-CRP) was higher than that of biomarkers measured alone and the NIHSS score. Conclusion Hs-CRP and HCY are independent pre-dictors of short-term outcome and mortality after AIS. Combined model may provide additional general prognostic information.关键词
急性缺血性脑卒中/超敏C-反应蛋白/同型半胱氨酸/预后/短期Key words
acute ischemic stroke/high-sensitivity C-reactive protein/homocysteine/prognosis/short-term分类
医药卫生引用本文复制引用
刘小野,董浩,涂文军,王屹,陈惠..超敏C-反应蛋白结合同型半胱氨酸预测急性缺血性脑卒中短期预后[J].中国康复理论与实践,2014,(4):347-350,4.基金项目
1.国家自然科学基金项目(No.81071605)；2.首都医科大学脑重大疾病实验室项目(No.2012NZDJ02)。 （No.81071605）
