中国临床药理学杂志Issue(4)：306-308,3.
转化生长因子βⅡ受体与人表皮生长因子受体2阴性乳腺癌患者预后的关系
Relation between transforming growth factor-βtypeⅡreceptor and progmosis of patients with human epidermal growth factor receptor-negative breast tumors
殷科 1郭宇1
作者信息
- 1. 宁波市第一医院 甲乳外科，浙江 宁波315010
- 折叠
摘要
Abstract
Objective To explore the relation between transforming growth factor-βtype II receptor ( TGF-βRⅡ) and the prognosis of hu-man epidermal growth factor receptor 2 ( HER2 ) -negative breast concer patients.Methods The expressions of TGF -β1 and TGF-βⅡwere de-tected by immunohistochemical in 102 HER2-negative breast tumours pa-tients.The correlation between the expressions and the clinicopathologic characteristics was analyzed.Results The positive expression rates of TGF-βⅡand TGF-β1 detected in HER2-negative breast cancer pa-tients were 39.22%and 31.37%.The 5-years overall survival rate of the TGF-βⅡ-positive patients (77.50%) was significantly higher than that of TGF-βⅡ-negitive patients (53.23%).The 5-years overall survival rate of the TGF-β1-positive patients (71.88%) was significantly higher than that of TGF -β1-negitive patients (45.71%).The COX proportion-al hazard model showed that expressions of TGF -βⅡand estrogen recep-tor ,tumor size and lymph node involvement were independent factors influ -encing on prognostic.Conclusion TGF-βⅡcan be used to judge the progrosis of HER2-negative breast cancer patients .关键词
转化生长因子βⅡ受体/人表皮生长因子受体2/乳腺癌/预后Key words
transforming growth factor-βtype II receptor/human epi-dermal growth factor receptor 2/breast tumours/prognosis分类
医药卫生引用本文复制引用
殷科,郭宇..转化生长因子βⅡ受体与人表皮生长因子受体2阴性乳腺癌患者预后的关系[J].中国临床药理学杂志,2014,(4):306-308,3.
