中国老年保健医学Issue(6)：9-11,12,4.DOI:10.3969/j.issn.1672-4860.2013.06.003
紫杉醇脂质体联合卡培他滨治疗晚期胃癌临床观察
Clinical observation of paclitaxel liposome combined with capecitabine in the treatment of advanced gastric cancer
摘要
Abstract
Objective To evaluate the efficacy and toxic side effects of paclitaxel liposome combined with capecitabine for trea -ting 34 patients with advanced gastric cancer.Methods A total of 64 patients with advanced gastric cancer were enrolled and as-signed to experimental group (paclitaxel liposome combined with capecitabine as PC regimen ,34 cases) and control group (docetax-el,cisplatin and 5-fluorouracil as DCF regimen,30 cases).Control group was treated with DCF regimen:docetaxel 75mg/m2,d1, cisplatin 20mg/m2 ,d1~5 and 5-fluorouracil 350mg/m2 ,d1~5,21d/cycle.Experimental group was given PC regimen:paclitaxel liposome 135mg/m2,d1;capecitabine 2000mg/(m2· d),po,bid,d1~14,21d/cycle.Results Control group:the total chemothera-py time was 122 cycles,averagely 4.07 cycles.Two patients got complete remission (CR),12 partial remission (PR),7 stable dis-ease (SD) and 9 progressive disease (PD).The short -term response rate (RR) was 46.7%,disease control rate (DCR) was 70%,median progression free survival ( mPFS) was 6.9 months and median overall survival ( mOS) was 12.5 months.Experimental group:the total chemotherapy time was 169 cycles,averagely 4.97 cycles.Fourteen patients got PR,9 SD and 11 PD.The short -term RR was 41.2%,DCR was 67.6%,mPFS was 6.2 months and mOS was 12 months.There were no significant differences re-garding RR,DCR,progression -free survival curves and overall survival curves of two groups.The major toxic side effects of two groups are hematologic toxicities.The incidences of leukopenia and anemia at grades Ⅲ~Ⅳin control group and experimental group were 56.7%and 17.6%as well as 13.3%and 2.9%,respectively.Conclusion Paclitaxel liposome combined with capecitabine as the first line chemotherapy for advanced gastric cancer is effective ,tolerable,and recommendable.关键词
晚期胃癌/药物疗法/紫杉醇脂质体/卡培他滨Key words
advanced gastric carcinoma/drug therapy/paclitaxel liposome/capecitabine引用本文复制引用
陆明洁,王建,刘平,束永前..紫杉醇脂质体联合卡培他滨治疗晚期胃癌临床观察[J].中国老年保健医学,2013,(6):9-11,12,4.基金项目
中国高校医学期刊临床专项资金 （）
