中国脑血管病杂志Issue(4)：173-177,5.DOI:10.3969/j.issn.1672-5921.2014.04.002
颈动脉钙化对缺血性卒中患者预后的影响
Effect of carotid calcification on the prognosis in patients with ischemic stroke
摘要
Abstract
Objective To investigate the relationship between the carotid calcification and the prognosis in patients with ischemic stroke. Methods A total of 522 patients with non-cardiac ischemic stroke registered in the Nanjing Stroke Registry Program (NSRP )from December 2009 to October 2012 were enrolled. All patients underwent head and neck CT angiography (CTA). The original data of CT scan were transmitted into the Siemens workstation. Calcium score measurement was performed using the same reconstruction conditions and Agatston calcium score to measure calcification score. The patients were divided into no (0),mild (0 <score <100)and severe calcification (≥100)groups according to their scores. The baseline clinical data of the patients were recorded. The occurrence of primary endpoint events within 2 years after stroke was followed up (ischemic stroke,myocardial infarction,and cardiovascular death). Multivariate COX regression analysis was used to evaluate the effect of carotid calcification score on the primary endpoint events. Kaplan-Meier survival curve was used to analyze the prognosis of patients with different degrees of calcification. Results The median carotid calcification score in 522 patients was 11.9 (quartiles:0,107. 9),in which 183 (35. 1%)were in the no calcification group,200 (38. 3%)were in the mild calcification group,and 139 (26. 6%)were in the severe calcification group. A total of 52 patients had a primary endpoint event at follow-up to 2 years. Multivariate COX regression analysis showed that age (HR, 1.034,95%CI 1. 006-1. 062;P=0. 017)and carotid artery calcification (HR,1. 001,95%CI 1. 000-1.001;P=0. 037)were the independent risk factors for the prognosis of ischemic stroke. Kaplan-Meier analysis showed that the 2-year cumulative incidences of the primary endpoint events were 5. 5%(n=10),9. 7%(n=16 ),and 15. 0%(n = 26 ),respectively in the no,mild and severe calcification groups. The incidence of endpoint event of the severe calcification group was significantly higher than that of the no calcification group (HR,1.612,95%CI 1.106-2.350;P=0.013). Conclusion Carotid calcification may be an important influencing factor for the prognosis in patients with ischemic stroke.关键词
脑缺血/卒中/颈动脉粥样硬化/预后/动脉钙化Key words
Brain ischemia/Stroke/Carotid atherosclerosis,Prognosis/Artery calcification引用本文复制引用
张雨蒙,徐格林,王莉,曹立平,郑玲,张治中,张宗军,蔡必扬,刘新峰,卢光明..颈动脉钙化对缺血性卒中患者预后的影响[J].中国脑血管病杂志,2014,(4):173-177,5.基金项目
国家自然科学基金资助项目（81220108008，81070922）；江苏省自然科学基金重点研究专项 （）
