中国全科医学Issue(10)：1119-1123,5.DOI:10.3969/j.issn.1007-9572.2014.10.010
青年和中老年原发性高血压病伴阻塞性睡眠呼吸暂停低通气综合征患者的临床特点研究
Clinical Observation of Young, Middle and Old Aged Patients with Hypertension and Obstructive Sleep Apnea-hypop-nea Syndrome (OSAHS)
蒋倩倩 1周晓欢 1陈玉岚 1张向阳 1徐新娟 1珠勒皮亚·司马义 1叶红2
作者信息
- 1. 830054 新疆维吾尔自治区乌鲁木齐市，新疆医科大学第一附属医院高血压科
- 2. 830054 新疆维吾尔自治区乌鲁木齐市，新疆医科大学第一附属医院呼吸二科
- 折叠
摘要
Abstract
O bjective To discuss the clinical features of young , middle and old aged patients with essential hyperten -sion and OSAHS.Methods The retrospective analysis was conducted of the clinical data of 353 patients with essential hyperten-sion and OSAHS diagnosed by the Hypertension Department of the First Teaching Hospital of Xinjiang Medical University from January 2011 to July 2013.The patients were divided into young group (136 patients) and the middle and old aged group (217 patients) by age and then the differences of general clinical data , sleep apnea monitoring indexes , 24-hour ambulatory blood pressure, renin-angiotensin-aldosterone system activity between the young group and the middle and old aged group were ana -lyzed.Results (1) The differences of sex composition ratio , drinking composition ratio, fasting blood-glucose (FBG), tria-cylglycerol ( TG) , total cholesterol ( TC) , low-density lipoprotein cholesterol ( LDL-C) and lipoprotein a 〔LP (α)〕 of the young group and middle and old aged group were not statistically significant ( P>0.05); the smoking composition ratio and body mass index ( BMI) of the young group were higher than that of the middle and old aged group and the high -density lipoprotein cholesterol( HDL-C) of the young group was lower than that of the middle and old aged group , and the differences were statisti-cally significant (P<0.05); (2) the apnea hypopnea index (AHI) and time of oxyhemoglobin saturation of less than 85%(TS <85%) of the middle and old aged group were higher than that of the young group and the mean oxygen saturation ( MSaO2 ) and the lowest oxygen saturation ( LSaO2 ) of the middle and old aged group were lower than that of the young group , the differences between the two groups were statistically significant (P<0.05); (3) the 24-hour mean systolic blood pressure (24 hSBP) and 24-hour mean diastolic blood pressure (24 hDBP) of the young group were higher than those of the middle and old aged group and the hypertension course of the middle and old aged group was longer than that of the young group , the differences were statis-tically significant(P>0.05); the difference of the 24-hour mean pulse pressure (24 hPP) between the young group and the middle and old aged group was not statistically significant (P>0.05); (4) the levels of angiotensin A1 and A2 of the young group in supine and standing was higher than that of the middle and old aged group and the level of aldosterone of the young group in supine was lower than that of the middle and old aged group , the differences were statistically significant ( P<0.05); and there was no difference of the levels of aldosterone in standing between the two groups ( P>0.05) .Conclusion During the pre-ventive treatment of the young , middle and old aged patients with essential hypertension and OSAHS , attentions should be paid to quitting smoking , losing weight , reducing the angiotensin activity and strengthening the depressurization efforts for the young pa -tients; attentions should be paid to reducing the aldosterone activity and adopting non -invasive positive airway pressure to modify the disease for the middle and old aged patients.关键词
原发性高血压/阻塞性睡眠呼吸暂停低通气综合征/青年/中老年/临床特点Key words
Essential hypertension/OSAHS/Young people/Middle and old aged people/Clinical feature分类
医药卫生引用本文复制引用
蒋倩倩,周晓欢,陈玉岚,张向阳,徐新娟,珠勒皮亚·司马义,叶红..青年和中老年原发性高血压病伴阻塞性睡眠呼吸暂停低通气综合征患者的临床特点研究[J].中国全科医学,2014,(10):1119-1123,5.
