中国全科医学Issue(10)：1124-1128,5.DOI:10.3969/j.issn.1007-9572.2014.10.011
老年慢性阻塞性肺疾病稳定期患者下呼吸道细菌定植与细胞免疫功能缺陷的关系研究
Relationship between Lower Airway Bacterial Colonization and Cellular Immunodeficiency of Stable Phase COPD Pa-tients
摘要
Abstract
Objective To investigate the relationship between lower airway bacterial colonization ( LABC) and airway inflammation or cellular immunity of stable phase COPD patients.Methods 50 elderly stable phase COPD patients ( aged≥65 years) with clear diagnosis in the department of respiratory (observed group), Fuxing Hospital Affiliated to Capital University of Medical Sciences between January 2011 to December 2012 was compared with 30 recruiting healthy people in the same age who re-ceived health examination in the medical examination center ( control group ) on interleukin ( IL) -8, hs-CRP, CD4 +, CD8 +and CD4 +/CD8 +in the induced sputum , after monitored quantitative bacterial culture , and blood.Results Among the 50 subjects, 64.0%showed LABC with bacterial loads >106cfu/ml.Pathogenic bacteria included Hemophilus influenza (27.8%), Streptococcus pneumoniae ( 16.7%) , Catarrhal Moran bacteria ( 13.9%) , Hemophilus parainfluenza ( 11.1%) , Bacillus coil ( 8.3%) , Pseudomonas aeruginosa ( 8.3%) , Staphylococcus aureus ( 5.6%) , Baumanii ( 5.6%) and Fungus (2.7%) .4 cases were with two kinds of pathogens (11.1%).The concentration of IL -8 in sputum and IL-8 and hs-CRP in blood of the patients with LABC were (408.73 ±286.09)ng/L, (63.49 ±42.98) ng/L, (12.15 ±8.13) mg/L and were (242.61 ±85.52) ng/L, (36.66 ±11.91) ng/L, (6.50 ±3.97) mg/L of the patients without LABC respectively.Significant difference was found in the two groups (P<0.05) .The levels of CD4 +, CD8 +and CD4 +/CD8 +were (38.40 ±4.92)%、(24.32 ±8.76)%、 (1.89 ±0.90) in healthy group.The levels of CD4 +, CD8 +and CD4 +/CD8 +were (36.37 ±8.26)%、(28.96 ±7.45)%、 (1.29 ±0.27) in group with LABC and (25.06 ±5.97)%、 (36.44 ±9.30)%、 (0.73 ±0.31) in group without LABC.Significant difference were found in these three groups ( P<0.05 ) .Conclusion LABC is found in a good portion of elderly stable COPD patients.It can appear more than one bacterial colonization.Stable COPD with LABC patients clear-ly suffer from airway inflammation and immunodeficiency and they three might influence each other and lead to exacerbations of COPD.关键词
肺疾病, 慢性阻塞性/下呼吸道/细菌定植/气道炎性反应/细胞免疫缺陷Key words
Pulmonary disease , chronic obstructive/Low airway/Bacterial colonization/Airway inflammation/Cellular immunodeficiency分类
医药卫生引用本文复制引用
陈谨,何耀红,呼玮,朱瑞霞,刘淑梅,张萍,崔建英..老年慢性阻塞性肺疾病稳定期患者下呼吸道细菌定植与细胞免疫功能缺陷的关系研究[J].中国全科医学,2014,(10):1124-1128,5.基金项目
北京市西城区创新资金 （）
