摘要
Abstract
Objective To analyze the clinical characteristics , prognosis of pediatric pneumococcal meningitis ( PM) and explore its prognosis influencing factors .Methods The clinical data of 98 PM child patients admitted to Beijing Children′s Hospital from January 2002 to April 2012 were collected retrospectively .98 PM child patients were divided into three groups , the clinical features were compared between different age groups .Glasgow score was used to divide the patients into groups A ( hav-ing good prognosis ) , B ( having poor prognosis ) .The clinical data of 2 groups were analyzed comparatively , and multivariate Logistic regression analysis used to analyze its prognosis influencing factors. Re sults 64 cases in below-1-year-old group , 18 cases in 1 to 5-year-old group, 16 cases in over-5-year-old group.The children from varying age groups had a fever . The incidences of high fontanelle tension and seizure were higher in below -1-year-old group than in the other 2 groups; the incidences of coma , confusion higher in 1~5-year-old group than in the other 2 groups; the incidences of headache , vomi-ting higher in over-5-year-old group than in the other 2 groups ( P<0.05 ) .Cerebrospinal fluid drug sensitive test suggested that the drug resistance rate of pneumococcus was 53.8%to penicillin , 100.0%to vancomycin .There was significant difference in incidences of CRP>100 mg/L, serum sodium <135 mmol/L, serum calcium<2.2 mmol/L between below -1-year-old groups from groups A , B ( P<0.05 ) .Multivariate Logistic regression analysis showed than the above -mentioned indexes were factors influencing the prognoses of PM children ( P<0.05 ) .Conclusion Below-1-year-old children is prone to PM , and more in boys than in girls.Its clinical features are mainly fever , headache, abnormal mental reactions, seizures etc.Age below 1 year, CRP>100 mg/L, hyponatremia, hypocalcemia suggests poor prognosis .关键词
脑膜炎, 肺炎球菌性/体征和症状/预后/危险因素Key words
Meningitis, pneumococal/Signs and symptoms/Prognsis/Risk factor分类
医药卫生
