中国比较医学杂志Issue(4)：47-50,4.DOI:10.3969/j.issn.1671.7856.2014.004.011
BALB／c 突变卷毛小鼠皮肤组织结构的分析
Histological analysis of the skin in BALB/c mutant mice with curly hair
李晓娟 1李硕 2白冰珂 1胡燕 1李蓓 1侯俊 1李瑞生1
作者信息
- 1. 解放军第302医院实验技术研究保障中心，北京 100039
- 2. 解放军第302医院医务部，北京 100039
- 折叠
摘要
Abstract
Objective To investigate if there are differences in the skin tissue structure between BALB /c mutant mice with curly hair and normal BALB/c mice.Methods 10-d,21-d,42-d and 63-d old groups of BALB/c mutant curly mice and normal BALB/c mice were used in this study , 10 mice in each group .The gross appearance of the mice were observed.Hair follicle and skin structure were examined and compared by histopathology .Results Clothing hair of the BALB/c mutant curly mice became bent at 10 day after birth ,and could be distinguished from normal mice of the same age . Histological observation showed that the number of hair follicles and hair roots of BALB /c mutant curly mice was significantly less than that of normal mice , and the sparse coat and hair curling characteristics were obviously kept to 21 d, 42 d and 63 d of age.Histopathological examination revealed that the number of hair follicles in the mice in the four age groups of BALB/c mutant curly mice was also significantly less than that of normal mice .At 63 days of age , bending curly hair growing in hair follicles were visible in the BALB/c mutant curly mice .Conclusion Hair follicles and the skin tissue structure in the BALB/c mutant curly mice and normal mice showed distinct differences .These results demonstrate that the skin structure of mutant mice is also changed , which can provide a theoretical reference for future research on the mouse curly hair mutant gene and model application .关键词
BALB/c小鼠/突变/卷毛/皮肤结构Key words
BALB/c mouse/Mutant curl/Curly hair/Skin structure分类
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李晓娟,李硕,白冰珂,胡燕,李蓓,侯俊,李瑞生..BALB／c 突变卷毛小鼠皮肤组织结构的分析[J].中国比较医学杂志,2014,(4):47-50,4.
