中国实用口腔科杂志Issue(11)：664-667,4.
呼吸道内具核梭杆菌与阻塞性肺疾病相关性研究
Detection and study of Fusobacteriumnucleatumin the acute exacerbation of chronic obstructive pulmonary disease
摘要
Abstract
Objective To detect the presence of Fusobacterium nucleatum(Fn.)in the acute exacerbation of chronic ob-structive pulmonary disease(AE-COPD)and to investigate its relationship with FEV1 and periodontal index. Methods The sputum samples of AE-COPD were collected and were extracted DNA of bacterium. The amount of Fn. and the to-tal number of bacterial cells were determined by real-time PCR based on SYBR@Green I Premix Ex TaqTM. FEV1 and periodontal parameters of each AE-COPD were recorded,and then investigate the relationship between Fn. and FEV1 and periodontal index. The data were statistically analyzed using SPSS17.0 software. Results The detection rate of Fn. was 60.38%and the relative quantity of Fn. was(44.58 ± 16.47)%. There was negative correlation between the relative quantity of Fn. and FEV1(P<0.05). There was positive correlation between the relative quantity of Fn. and simplified oral hygiene index and clinical attachment loss(P<0.05). Conclusion Fn. can colonize in the sputum samples in the AE-COPD and colonization of Fn. is relevant to FEV1 and periodontal parameters.关键词
具核梭杆菌/慢性阻塞性肺疾病急性加重/牙周炎Key words
Fusobacterium nucleatum/acute exacerbation of chronic obstructive pulmonary disease/periodontitis分类
医药卫生引用本文复制引用
谭丽思,王宏岩,赵海礁,潘亚萍,康健..呼吸道内具核梭杆菌与阻塞性肺疾病相关性研究[J].中国实用口腔科杂志,2013,(11):664-667,4.基金项目
“十一五”国家科技支撑计划 （）
