中国药理学与毒理学杂志Issue(2)：279-282,4.DOI:10.3867/j.issn.1000-3002.2014.02.023
使用暴露边界比法进行我国居民乙酰甲胺磷膳食暴露风险评估
Probabilistic risk assessment of the dietary exposure of Chinese population to acephate using margin of exposure
摘要
Abstract
OBJECTIVE Calculate the dietary exposure and exposure risk of Chinese consumers to acephate,using the margin of exposure method.METHODS Determine the bench mark dose of acephate by 21 -day gavage experiment of rats.According to the data from the 2002 National Diet and Nutrition Survey,the 2000 -2006 national food conta mination monitoring program,the 2005 -2006 export monitoring data of customs,calculate the dietary exposure of Chinese consumers to acephate by probabilistic assessment.Estimate the exposure risk by co mparing the margin of exposure with 100. RESULTS The bench mark dose of acephate was 0.75 mg·kg -1 ,the BMDL was 0.51 mg·kg -1 .The exposure of children was higher than that of adults.The proportion at risk of group 1 -6 y,7 -17 y and 18 y or higher was 5%,1 % and 0.1 %,respectively.CONCLUSION So me consumers was of dietary exposure risk to acephate.The high exposure of children should be of great concern.关键词
乙酰甲胺磷/膳食暴露风险/暴露边界比Key words
acephate/dietary exposure risk/margin of exposure分类
医药卫生引用本文复制引用
乙楠楠,吴惠,姚欣雅,赵敏娴,曹正颖,王灿楠..使用暴露边界比法进行我国居民乙酰甲胺磷膳食暴露风险评估[J].中国药理学与毒理学杂志,2014,(2):279-282,4.基金项目
国家自然科学基金（81072304）；国家自然科学基金（81273080）@@@@The project supported by National Natural Science Foundation of China （81072304）；and by National Natural Science Foundation of China （）
