中国药物经济学Issue(4)：18-20,3.
四氢化吡咯二硫代氨基甲酸酯干预大鼠急性胰腺炎核因子-κB的表达及作用
The Expression and Role of Nuclear factor kappa B in Acute Pancreatitis of Rats
摘要
Abstract
Objective To investigate the nuclear factor kappa B (NF- κB) and TNF- α in rats with acute pancreatitis(AP) in the evaluation of expression,four hydrogenation of pyrrole two thiocarbamate(PDTC) protective effect on pancreatic injury.Methods 54 Wistar rats,were randomly divided into control group,model group,the intervention group.Third,6,12 hours after anesthesia and left ventricular blood executed in modeling,the pancreas tissue pathological changes;Determination of content of NF-κB and TNF-α double antibody sandwich ABC-EL method ISA.Results Compared with the control group,the rats in the model group,with the passage of serum amylase and the plasma levels of NF-κB,TNF-αand pancreatic pathological time scores increased significantly (P<0.01),positive correlation between the two indexes (r=0.483,P<0.05);compared with the model group,the intervention group blood amylase increase and NF- κB α,TNF- content decreased,hemorrhage,necrosis and reduce pancreatic tissue(P<0.05).Conclusion NF-κB activation mediated upregulation of TNF-α in L-arginine induced AP occurrence, development intervention;PDTC NF-κB activation improve inflammat.关键词
急性胰腺炎/核因子-κB/四氢化吡咯二硫代氨基甲酸酯Key words
Acute pancreatitis/Nuclear factor kappa B/Four hydrogenation of pyrrole two thiocarbamate分类
医药卫生引用本文复制引用
崔香丹,金明杰,付瑶..四氢化吡咯二硫代氨基甲酸酯干预大鼠急性胰腺炎核因子-κB的表达及作用[J].中国药物经济学,2014,(4):18-20,3.基金项目
延边大学科技发展计划项目，延大科合字（2010）第024号 （）
