中国医学创新Issue(31)：15-16,17,3.DOI:10.3969/j.issn.1674-4985.2013.31.006
阿托伐他汀对急性冠脉综合征患者血清基质金属蛋白酶-9的影响
The Atorvastatin Affect Serum Matrix Metalloproteinase -9 Level in Acute Coronary Syndrome Patients
李道远 1玛依努尔·斯买拉洪 2陈苗苗2
作者信息
- 1. 山东省潍坊市第二人民医院 山东 潍坊 261041
- 2. 新疆自治区中医院
- 折叠
摘要
Abstract
Objective:To observe serum matrix metalloproteinase -9(MMP-9)level in the acute coronary syndrome(ACS)patients after atorvastatin therapy. Method:90 ACS patients for the study group,unstable angina pectoris 45 cases(UAP group)and acute myocardial infarction 45 cases(AMI group),were admitted to hospital .except for the basic treatment,each patient was taken 20mg atorvastatin one day,and was measured the serum MMP-9 level before and after treatment. 30 patients healthy control group was measured serum MMP-9 level. Result:Study group serum MMP-9 levels was significantly higher than that in the control group(P<0.01);Both of the UAP group and AMI group serum level of MMP-9 was significantly lower than pretreatment(P<0.01).Conclusion:Atorvastatin significantly reduces serum MMP-9 level in patients with ACS,and plays a role in atherosclerotic plaque stability.关键词
基质金属蛋白酶-9/阿托伐他汀/急性冠脉综合征Key words
Matrix metalloproteinase-9/Atorvastatin/Acute coronary syndrome引用本文复制引用
李道远,玛依努尔·斯买拉洪,陈苗苗..阿托伐他汀对急性冠脉综合征患者血清基质金属蛋白酶-9的影响[J].中国医学创新,2013,(31):15-16,17,3.
