中国医学创新Issue(31)：35-37,3.DOI:10.3969/j.issn.1674-4985.2013.31.015
联合检测类风湿因子、抗环瓜氨酸多肽抗体和抗角蛋白抗体在类风湿关节炎诊断中的价值
Diagnostic Values of Combined Detection of Rheumatoid Factor,Anticyclic Citrullinated Peptide Antibody and Antikeratin Antibody in Rheumatoid Arthritis
陈朴 1张立营 1李熙建 1龙琴1
作者信息
- 1. 四川省宜宾市第一人民医院 四川 宜宾 644000
- 折叠
摘要
Abstract
Objective:To evaluate the significance of the combination of serum rheumatoid factor(RF),anticyclic citrullinated peptide antibody(anti CCP)and antikeratin antibody in the diagnostic value of rheumatoid arthritis(RA).Method:Serum from 150 RA patients and 75 non-RA patients were analyzed.RF,anti CCP and AKA were detected using immune turbidimetry、ELISA and indirect immunofluorescence respectively.The distributions of these antibodies were compared to determine the diagnostic values of combined detection of RF,anti CCP and AKA in RA patients.Result:The sensitivity of single antibody detection in RF was the highest(82.0%),specificity of AKA was the highest(93.33%),the positive predictive value of AKA was the highest(94.05%),and negative predictive value of RF was the highest(67.47%);the sensitivity of combined detection of anti CCP antibody to RF+in the highest(43.33%),specificity to RF+anti CCP+AKA was the highest(100%),the positive predictive value for RF+anti CCP+AKA was the highest (100%),and negative predictive value of RF+anti CCP antibody was highest(44.81%).Conclusion:RF diagnosis of RA sensitivity is highest,but specific to RF+anti CCP+AKA is the highest,the three combined detection can improve the diagnostic value of the RA.关键词
类风湿关节炎/类风湿因子/抗环瓜氨酸多肽抗体/抗角蛋白抗体Key words
Rheumatoid arthritis/Rheumatoid factor/Anticyclic citrulline peptide antibody/Antikeratin Antibody引用本文复制引用
陈朴,张立营,李熙建,龙琴..联合检测类风湿因子、抗环瓜氨酸多肽抗体和抗角蛋白抗体在类风湿关节炎诊断中的价值[J].中国医学创新,2013,(31):35-37,3.
