中国医学创新Issue(32)：11-12,2.DOI:10.3969/j.issn.1674-4985.2013.32.005
不同糖皮质激素诱导治疗肾病综合征的临床疗效对比及作用机制探讨
Clinical Efficacy and Mechanism of the Different Glucocorticoid in the Treatment of Nephrotic Syndrome Induced
李涛 1冯晓晨1
作者信息
- 1. 大连大学附属中山医院 辽宁 大连 116001
- 折叠
摘要
Abstract
Objective:To explore the clinical efficacy and mechanism of the different glucocorticoid in the treatment of nephrotic syndrome induced.Method:According to a stratified randomization method,85 cases of patients with nephrotic syndrome were divided into the prednisone group and the methylprednisolone group,24 h urine protein,SCr,BUN,urinary protein clearance time and the clinical efficacy of the two groups were observed. Result:The urinary protein clearance time of the methylprednisolone group was(6.3±1.6)d,24 h urinary protein excretion was(128.3±23.6)mg, the urinary protein clearance time of the prednisone group was(11.5±1.4)d,24 h urinary protein excretion was(289.5±31.7)mg,the difference between the two groups was significant(P<0.05).The total effective rate of the methylprednisolone group was 94.1%(48/51),the total effective rate of the prednisone group was 70.6%(24/34),the difference between the two groups was significant(P<0.05). Conclusion:Different clinical efficacy of the different corticosteroids in the treatment of nephrotic syndrome,methylprednisolone safe and effective.关键词
糖皮质激素/肾病综合征/临床疗效Key words
Glucocorticoids/Nephrotic syndrome/Clinical efficacy引用本文复制引用
李涛,冯晓晨..不同糖皮质激素诱导治疗肾病综合征的临床疗效对比及作用机制探讨[J].中国医学创新,2013,(32):11-12,2.
