中国医学创新Issue(35)：1-2,3,3.DOI:10.3969/j.issn.1674-4985.2013.35.001
B型脑钠肽和D-二聚体在慢性肺源性心脏病患者中检测的临床意义
Clinical Significance of B Type Natriuretic Peptide and D-dimer in Patients with Chronic Pulmonary Heart Disease Detection
郭春霞1
作者信息
- 1. 河南省商丘市第一人民医院 河南 商丘 476100
- 折叠
摘要
Abstract
Objective:To study the B-type natriuretic peptide(BNP)and D- dimer(D-dimer)levels in patients with chronic pulmonary heart disease(CPHD)and analyze its clinical significance.Method:Plasma D-dimer content by nephelometry and B-type natriuretic peptide levels by immunofluorescence assay were detected in patients with simple chronic obstructive pulmonary disease(COPD),chronic pulmonary heart disease (CPHD)in acute exacerbation and remission respectively,pH value,PaO2 and PaCO2 were determined by blood gas analyzer.Differences of the content of BNP,the D-dimer levels and arterial blood gas analysis were observed and compared among the groups.Result:Plasma D-dimer content in patients with chronic pulmonary heart disease in acute exacerbation and remission were(2.74±0.87)μg/L,(2.09±0.77)μg/L respectively,they were significantly higher than that in patients with simple obstructive pulmonary disease [(1.67±0.65)μg/L],there were statistically significant differences(P<0.05).The BNP levels showed significant difference among the groups of patients with CPHD in acute exacerbation and remission was (919.34±189.33)pg/mL,(213.60±31.74)pg/mL,they were significantly higher than the COPD group [(37.30±12.74)pg/mL],the groups differences were statistically significant(P<0.01).The content of PaO2 was negatively correlated with BNP,D-dimer,and positively correlated with PaCO2(P<0.05).Conclusion:Combined detection of B type natriuretic peptide and D-dimer level has important clinical significance to evaluate severity,therapeutic effect and prognosis in patients with CPHD.关键词
慢性肺源性心脏病/B型脑钠肽/D-二聚体Key words
Chronic pulmonary heart disease/B-type natriuretic peptide/D-dimer引用本文复制引用
郭春霞..B型脑钠肽和D-二聚体在慢性肺源性心脏病患者中检测的临床意义[J].中国医学创新,2013,(35):1-2,3,3.
