中国医学创新Issue(3)：47-49,3.DOI:10.3969/j.issn.1674-4985.2014.03.019
甲胎蛋白异质体和甲胎蛋白信使核糖核酸用于诊断肝细胞癌
Alpha Fetoprotein Heterogeneity and Alpha Fetoprotein Messenger Ribonucleic Acid for Diagnosis of Hepatocellular Carcinoma
邱大鹏 1韩风 1贺涛1
作者信息
- 1. 河南省肿瘤医院 郑州大学附属肿瘤医院 河南 郑州 450008
- 折叠
摘要
Abstract
Objective:To investigate the combined detection of 2 tumor markers in serum alpha fetoprotein(AFP)variants(AFP-L3)and alpha fetoprotein messenger ribonucleic acid(AFPmRNA)value and evaluate prognosis significance in diagnosis of hepatocellular carcinoma.Method:From April to July 2005,82 cases of hepatocellular carcinoma(HCC),11 patients with chronic hepatitis B cirrhosis with portal hypertension and 19 cases of benign liver tumors were treated with enzyme-linked assay and fluorescence quantitative PCR and detection of AFP-L3 and AFPmRNA level,compared the positive rate;and 1 month after the detection of liver cancer patients and AFPmRNA AFP-L3 level statistics make survival curve. Result:Through AFPmRNA and AFP-L3 joint detection,positive rate was 64.3%,significantly higher than the separate detecting AFP-L3,AFP,AFP-mRNA positive rate was high (50.9%,40.2%). And there were statistically significant(P<0.05);Preoperative and postoperative joint detection of AFP-L3 and AFPmRNA positive patients with postoperative 3 year survival rate were low. Conclusion:Preoperative two indexes of combined detection of APF-L3 and AFPmRNA can improve the diagnosis of HCC,especially AFP negative rate of HCC,and after the combined detection of HCC and to evaluate the clinical significance.关键词
原发性肝癌/甲胎蛋白异质体/甲胎蛋白信使核糖核酸/诊断/预后Key words
Primary liver cancer/Alpha fetoprotein heterogeneity/Alpha fetoprotein messenger ribonucleic acid/Diagnosis/Prognosis引用本文复制引用
邱大鹏,韩风,贺涛..甲胎蛋白异质体和甲胎蛋白信使核糖核酸用于诊断肝细胞癌[J].中国医学创新,2014,(3):47-49,3.
