中国医学创新Issue(6)：3-5,3.DOI:10.3969/j.issn.1674-4985.2014.06.002
难治性癫痫患者脑内HIF-1α与多药耐药基因1表达的相关性及其意义
Expressions and Correlation of HIF-1αand Multidrug Resistance Gene 1 in Brain Tissues of Patients with Refractory Epilepsy and Its ;Significance
摘要
Abstract
Objective:To explore expressions and correlation of hypoxia induced factor 1α(HIF-1α)and multidrug resistance gene 1(MDR1) in the brain tissues of patients with refractory epilepsy.Method:Brain tissues were collected from 9 patients with refractory epilepsy and 7 cases of the control group.The expression of HIF-1αand MDR1 were examined by immunohistochemistry,and the correlation between the positive expression rates of HIF-1αand MDR1 were analyzed.Result:The positive expression rate of HIF-1αin refractory epilepsy group(77.8%)was higher significantly than that in control group(14.3%),the positive expression rate of MDR1 in refractory epilepsy group(66.7%)was higher significantly than that in control group(14.3%),the differences were statistically significant(P<0.05).The expression of HIF-1αwas positively correlated with the expression of MDR1(r=0.76,P<0.05).Conclusion:HIF-1αand MDR1 are over expressed in the brain of refractory epilepsy,and there is a positive correlation. HIF-1αmay be involved in the pathogenesis of refractory epilepsy by regulating the expression of MDR1 gene.关键词
缺氧诱导因子1α/多药耐药基因1/难治性癫痫Key words
Hypoxia induced factor 1α/Multidrug resistance gene 1/Refractory epilepsy引用本文复制引用
王广新,马衍辉,周荣双,于磊,伊长英,任士锋..难治性癫痫患者脑内HIF-1α与多药耐药基因1表达的相关性及其意义[J].中国医学创新,2014,(6):3-5,3.基金项目
国家自然科学基金项目（81071042）；济南市卫生科技计划项目 （）
