中国医学创新Issue(6)：36-39,4.DOI:10.3969/j.issn.1674-4985.2014.06.015
人宫颈癌组织中survivin的表达与临床分析
The Expression and Clinical Analysis of surviving in Cervical Cancer Tissues/D
丁玉梅 1马丽丽 2窦洪涛 1王新美 1丁宁 1于小辉1
作者信息
- 1. 山东省淄博市中心医院 山东 淄博 255036
- 2. 山东省潍坊市人民医院
- 折叠
摘要
Abstract
Objective:To observe the expression and location of survivin protein in human normal cervices,cervical intraepithelial neoplasia and cervical carcinoma,the relationship of survivin with the occurrence,development and prognostic of cervical carcinoma,and the clinical value of survivin for cervical carcinoma. Method:All of the paraffin tissue samples were gathered from one hospital in two years. The samples were divided three groups, 20 cases of normal cervices,25 cases of cervical intraepithelial neoplasia,and 52 cases of cervical carcinoma. The stains of survivin protein in the tissue samples with the immunohistochemistry methods were checked. Result:The stains of survivin in cervical tissue samples were located in cell nucleus and cytoplasm,mainly in cell nucleus. The positive rate of survivin was 5.0%in normal cervices,56.0%in cervical intraepithelial neoplasia,82.7%in cervical carcinoma. The correlation could be found of survivin with the clinical stage,histological differentiation and lymphatic metastasis of the cervical carcinoma. Conclusion:The correlation can be find of survivin with the occurance and progression the cervical carcinoma closely. Survivin will be a clinic valuable marker for the prevention,diagnosis,treatment,and judging the prognosis of human cervical carcinoma.关键词
宫颈癌/Survivin/表达Key words
Cervical carcinoma/Survivin/Expression引用本文复制引用
丁玉梅,马丽丽,窦洪涛,王新美,丁宁,于小辉..人宫颈癌组织中survivin的表达与临床分析[J].中国医学创新,2014,(6):36-39,4.
