中国医学创新Issue(6)：46-48,49,4.DOI:10.3969/j.issn.1674-4985.2014.06.018
腰间盘HIZ与TNF-α表达的相关性研究及其在椎间盘内破裂症中的诊断价值
The Correlation of Lumbar Disc HIZ and TNF-αExpression and Its Diagnostic Value in the Rupture Disc Herniation
李松军 1邝立鹏 1王兆杰 1安荣泽 1谭伟源 1方存迅1
作者信息
- 1. 遵义医学院第五附属 珠海 医院 广东 珠海 519100
- 折叠
摘要
Abstract
Objective:To investigate the relationship between the signal changes with TNF-αexpression in the lumbar disc tissues and the diagnostic value of HIZ in the ruptured intervertebral disc herniation.Method:38 IDD patients following discography were subjected to lumbar MRI, Pfirrmann grading and VAS scoring. Based on mild pain VAS scores,those cases were divided into group A,group B group with moderate pain and severe pain in Group C. According to Pfirrmann grading standards,cases were classified as classⅢmild degeneration in group D,Ⅳlevel was moderate to severe degenerative group F. TNF-αimmunohistochemical staining and HE staining were performed in disc tissues of patients with HIZ and non-HIZ,and 5 cases of intervertebral disc tissues removed during surgery in patients with spinal fractures were used as control.Result:The linear correlation on between the disc signal and the age were negatively correlated,R value was-0.6111,signal and intradiscal TNF-αexpression were negatively correlated,R value was-0.871 and the linear correlation coefficient. With pain symptoms,disc signal gradually weakened,group A,group B,group C disc signal change compared with the control group were significant differences(P<0.05).Disc degeneration and disc signal changes and the expression of TNF-α, group D than the group F were statistically significant(P<0.05). DD patients HIZ disc tissue between local inflammatory response significantly,TNF-αimmunohistochemical staining were positive;TNF-αexpression of HIZ group were significantly stronger than the non-HIZ group and the control group (P<0.05).Conclusion:Disc signal and age,TNF-αexpression and VAS scores negatively correlated significantly when the back pain increase with time HIZ disc signal decreased significantly. IDD patients with positive expression of TNF-αsignificantly HIZ,and HIZ can be used as a specific image of the IDD.关键词
椎间盘内破裂症/高信号区/磁共振成像/肿瘤坏死因子-α/免疫组化Key words
Ruptured intervertebral disc herniation/High signal area/Magnetic resonance imaging/Tumor necrosis factor-α/Immunohistochemistry引用本文复制引用
李松军,邝立鹏,王兆杰,安荣泽,谭伟源,方存迅..腰间盘HIZ与TNF-α表达的相关性研究及其在椎间盘内破裂症中的诊断价值[J].中国医学创新,2014,(6):46-48,49,4.
