中国医学创新Issue(8)：6-7,8,3.DOI:10.3969/j.issn.1674-4985.2014.08.003
乙肝病毒耐药导致慢性重型肝炎的抗病毒治疗临床疗效分析
Clinical Analysis of Antiviral Therapy for Chronic Severe Hepatitis Triggered by Drug-fast Hepatitis B Virus
丁岗强 1康谊 1刘俊平 1曾艳丽 1侯环荣 1魏君锋 1尚佳1
作者信息
- 1. 河南省人民医院 河南 郑州 450003
- 折叠
摘要
Abstract
Objective:To analyze the clinical effect of antiviral therapy for chronic severe hepatitis triggered by drug-fast hepatitis B virus.Method:73 patients who degenerated into chronic severe hepatitis after the treatment of oral nucleoside analogs in our hospital from December 2009 to December 2012 were selected,and they were divided into the control group for 38 cases and the observation group for 35 cases.The control group was given symptomatic treatment such as routine liver protection,anti choleplania and nutritional support,etc,the observation group was given nucleoside analogues entecavir on the basis of the control group.The mortality rate,HBV-DNA negative conversion rate were compared between the two groups;At the same time,the serum liver function indexes of alanine aminotransferase(ALT),total bilirubin(T-BILI),albumin(ALB)and prothrombin activity(PTA)were also detected and contrastive analyzed.Result:After 24 weeks’ treatment,the mortality rate of observation group was 2.86%,it was significantly lower than 18.42%of the control group(X2=4.523,P=0.036),the negative rate of HBV-DNA was 88.57%,it was higher than 39.47%of the control group(X2=16.408,P=0.000).In addition,there was no significant difference in serum ALT,ALB,TBIL and PTA levels between the two groups before treatment(P>0.05);After treatment,the ALT,TBIL in the control group were significantly higher than those in the observation group,while ALB,PTA were significantly lower than those in the observation group (P<0.05).Conclusion:For the hepatitis B virus resistance leading to chronic severe hepatitis patients,antiviral drugs can reduce the mortality of patients,improve patient HBV-DNA negative conversion rate,improve the liver function tests, worthy of clinical application.关键词
乙肝病毒耐药/慢性重型肝炎/抗病毒治疗/临床疗效Key words
Drug-fast hepatitis B virus/Chronic severe hepatitis/Antiviral therapy/Clinical effect引用本文复制引用
丁岗强,康谊,刘俊平,曾艳丽,侯环荣,魏君锋,尚佳..乙肝病毒耐药导致慢性重型肝炎的抗病毒治疗临床疗效分析[J].中国医学创新,2014,(8):6-7,8,3.
