摘要
Abstract
Objective:To study the effects of small-dose ketamine pretreatment on the cognitive function in elderly patients after orthopedic operation.Method:56 elderly patients(65-80 years old)in orthopedics for elective orthopedic lower limb surgery were randomly divided into the control group and the ketamine group,28 cases in each group.After induction of anesthesia,the ketamine group was given ketamine with 0.25 mg/(kg·h)by continuous intravenous infusion,the control group was given the same volume of saline.Tumor necrosis factor-α(TNF-α)and interleukin-6(IL-6)were detected 1 d before surgery,after 6 h,24 h,48 h and 72 h in peripheral blood.Mini Mental State Examination(MMSE)score were recorded 1 d before surgery,after 24 h,48 h,72 h,and cognitive function were evaluated.Result:The plasma level of TNF-αand IL-6 in the ketamine group increased extent after 6 h,24 h,48 h and the incidence rate of POCD 24 h,48 h, 72 h after surgery were significantly lower than those in the control group,the differences were statistically significant (P<0.05).Conclusion:Low dose ketamine pretreatment can reduce the incidence of postoperative early POCD,presumably it is related to anti-inflammatory response.关键词
氯胺酮/术后认知功能障碍/老年患者/炎症因子/骨科手术Key words
Ketamine/Postoperative cognitive dysfunction/Elderly patients/Inflammatory factors/Orthopedic surgery
