中国医学创新Issue(9)：24-25,26,3.DOI:10.3969/j.issn.1674-4985.2014.09.009
代谢型谷氨酸受体5 mRNA与脑梗死的相关性研究
The Study on Relationship between Metabotropic Glutamate Receptor 5 mRNA and Cerebral Infarction
刘莺 1张茂林 2杨巧莲 2刘俊平3
作者信息
- 1. 内蒙古自治区人民医院 内蒙古 呼和浩特市 010017
- 2. 包头医学院第一附属医院
- 3. 河南省驻马店市人民医院
- 折叠
摘要
Abstract
Objective:To investigate the correlation between mGluR 5mRNA and cerebral infarction.Method:Seventy-five male Wistar rats were randomly divided into normal control group,operation group 1,3,6,12,24 h and 3 d, 14 d groups and corresponding sham operation control group,the rat MCAO model was used in situ hybridization,was used to detect the expression of mGluR5 mRNA.Result:The normal group and the sham operation group had no difference at each time(P>0.05). Each time the operation group mGluR5 mRNA expression were higher than the sham operation control group and normal control group,ischemia 1 h and its expression is increased,and the difference were all statistically significant (P<0.05). The mGluR5 mRNA expression reached peak at 6 h(F=5.328,P<0.00),began to decline after 3 d(P<0.01), the basic dropped to normal control level after 14 d(P>0.05).Conclusion:MGluR5 increased after cerebral ischemia, suggesting that mGluR5 plays an important role in cerebral infarction,so as to point out a way for our clinical study.关键词
脑梗死/mGluR5/mRNAKey words
Cerebral infarction/mGluR5/mRNA引用本文复制引用
刘莺,张茂林,杨巧莲,刘俊平..代谢型谷氨酸受体5 mRNA与脑梗死的相关性研究[J].中国医学创新,2014,(9):24-25,26,3.
