Abstract
Objective:To evaluate the effect of exenatide on plasma glucose,weight and body fat in poorly controlled type 2 diabetes patients using oral antidiabetic drug.Method:15 cases of poorly controlled type 2 diabetes who used oral antidiabetic drug in our hospital were selected. Exenatide was injected subcutaneously together with the original basis of oral hypoglycemic agents for three months,and the body weight,body mass index(BMI),the percentage of body fat tissue, the percentage of fat tissue of waist to hip and visceral fat range were analyzed by body composition analyzer before and after treatment. In the mean time,Dual-energy X-ray absorptiometry was used to determine the fat mass and percentage,muscle and bone mineral salts mass of upper limb,Lower limb,trunk,and whole body. Result:After 3 months’treatment,HbA1c were significantly decreased than before,had statistical differences(t=3.472,P<0.01). The waistline,the hip circumference and the waist-hip ratio(WHR)were decreased than before,but no statistical difference(P>0.05). The body weight,BMI, the percentage of body fat and visceral fat range were significantly decreased before and after treatment(t=4.424,P<0.01;t=4.337,P<0.01;t=4.426,P<0.01;t=4.025,P<0.01). The fat tissue of waist-hip ratio was decreased than before,but no statistical difference(P>0.05). After 3 months’ treatment,the fat tissue mass of lower limb,trunk,and whole body were significantly decreased than before,had statistical differences(t=4.008,P<0.01;t=2.914,P<0.05;t=3.474,P<0.01). After 3 months’ treatment,the fat tissue mass percentage of lower limb,trunk,and whole body were significantly decreased, had statistical differences(t=2.405,P<0.05;t=2.756,P<0.05;t=2.281,P<0.05). The fat tissue mass and percentage of upper limb was decreased than before,but no statistical difference(P>0.05). The muscle and bone mineral salts mass were not altered(P>0.05). After 3 months’ treatment,the decrease of body weight was highly correlated with the decrease of trunk fat and whole body fat(r=0.860,0.819,P<0.01). The decrease of whole body fat was highly correlated with lower limb fat and trunk fat(r=0.834,0.955,P<0.01).Conclusion:Exenatide can effectively control the level of plasma glucose of patients which being poorly controlled by oral antidiabetic drug,decrease the body weight which depends on fat mass decrease,especially lower limb,trunk fat. Exenatide don’t affected on muscle and bone mineral salts mass.关键词
艾塞那肽/2型糖尿病/双能X线/电阻抗/体质成分Key words
Exenatide/Type 2 diabetes/Dual-energy X-ray/Electronic resistance/Body element
