摘要
Abstract
Objective:To explore the correlation between microalbuminuria(MAU),cystatinC(CysC)with contrast-induced nephropathy(CIN).Method:205 angina patients underwent percutaneous coronary intervention(PCI) from January 2011 to June 2013 in our hospital were selected,they were randomly divided into CIN group and non CIN group according to the occurrence of CIN.MAU,CysC and Scr of all patients were continuous detected before PCI and within 72 hours after PCI.The changes of above index among two groups were compared.Using logistic regression analysis, the association between MAU,CysC and CIN were assessed.Result:A total of 17 cases occurred CIN(8.29%)during in hospital.In CIN group,MAU and CysC levels changed in 24 hours and reached the peak in 48 h after PCI,it was significantly higher than those before contrast injection in CIN group and those after contrast injection of non-CIN group, respectively(P<0.05).The serum creatinine levels were similar to those before PCI in 24 h and it began to rise in 48 h in CIN group.It had significantly statistics differences in 48 h to 72 h compared with before contrast injection and non-CIN group (P<0.05).There was no significant difference between CysC,MAU and Scr levels before and after PCI at 24,48,72 h in non-CIN group(P>0.05).Multivariate logistic regression analysis,adjusted for age,sex,anemia,the amount of contrast medium and diabetes,display MAU,CysC were independent predictors of CIN(P<0.05).The amount of contrast agent samely associated with incidence of CIN(P<0.05).Conclusion:Changes of MAU,CysC can predict the occurrence of CIN in early stage,MAU,CysC may be the independent risk factors for CIN.关键词
尿微量白蛋白/胱抑素C/对比剂肾病/经皮冠状动脉介入/心绞痛Key words
Microalbuminuria/CystatinC/Contrast-induced nephropathy/Percutaneous coronary intervention/Angina
