中国癌症防治杂志Issue(3)：231-234,235,5.DOI:10.3969/j.issn.1674-5671.2013.03.09
非小细胞肺癌化疗同期调强放疗靶区变化规律的临床分析
Changes in tumor volume during intensity-modulated radiotherapy for non-small cell lung cancer
苏胜发 1卢冰 1马筑 1肖跃华 1欧阳伟炜 1李青松 1胡银祥 1栗蕙芹1
作者信息
- 1. 550004 贵阳 贵阳医学院附属医院/贵州省肿瘤医院胸部肿瘤科
- 折叠
摘要
Abstract
Objective To analyze changes in target tumor volume during intensity-modulated radiotherapy(IMRT)for non-small cell lung cancer(NSCLC). Methods A total of 25 NSCLC patients underwent IMRT.With the following dose series(Gy):20,30,40,50.5 and 61,simulation computed tomography scans were carried out before each treatment to measure changes in gross tumor volume (GTV)and gross target volume of mediastinal nodes (GTVnd). Results Both GTV and GTVnd decreased over the course of IMRT. The lowest dose causing significant changes from baseline was 40 Gy:GTV,t=5.019,P=0.000;GTVnd,t=5.267,P=0.000.IMRT was associated with significant decreases in GTV and GTVnd even after patients were grouped according to initial tumor volumes:GTV≥101.45 ml,t=6.019,P=0.000;GTV<101.45 ml,t=6.491,P=0.000;GTVnd≥50.35 ml,t=5.449,P=0.000;GTVnd<50.35 ml, t=7.919,P=0.000.However,volume changes were greater for larger tumors than for smaller ones. Conclusions GTV and GTVnd grad-ually decreased over the course of IMRT,with larger tumors showing greater decreases. Significant decreases in GTV and GTVnd oc-curred even after treatment at 40 Gy.关键词
肺肿瘤/非小细胞肺癌/调强放疗/肿瘤体积/变化Key words
Lung neoplasms/Non-small cell lung cancer/Intensity-modulated radiotherapy/Tumor volume/Change分类
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苏胜发,卢冰,马筑,肖跃华,欧阳伟炜,李青松,胡银祥,栗蕙芹..非小细胞肺癌化疗同期调强放疗靶区变化规律的临床分析[J].中国癌症防治杂志,2013,(3):231-234,235,5.
