中国癌症防治杂志Issue(4)：315-319,5.DOI:10.3969/j.issn.1674-5671.2013.04.07
HER-2及LRP在非小细胞肺癌中的表达及临床意义
Expression and clinical significance of HER-2 and LRP in non-small cell lung cancer
侯慧 1高爽 1任秋华 1肖明明 1景士兵1
作者信息
- 1. 110016 沈阳 辽宁省人民医院病理科
- 折叠
摘要
Abstract
Objective To investigate associations between the expression of lung resistance protein(LRP)and human epidermal growth factor receptor 2(HER-2)and the clinico-pathological features of non-small cell lung cancer. Methods The two-step EnVision immunohistochemical method was used to measure the expression of HER-2 and LRP in 70 cases of non-small cell lung cancer tissues, and 35 corresponding adjacent normal lung tissues. Results Expression rates of HER-2 and LRP were significantly higher in cancer tissue(31.4%and 72.9%,respectively)than in adjacent normal lung tissue(P<0.05). The expression rate of HER-2 was significantly higher in adenocarcinoma (46.0%)than in squamous cell carcinoma (15.2%;P<0.05). However,HER-2 expression did not correlate with lymph node metastasis,pathologic classification or clinical staging (P>0.05).The expression rate of LRP was similar in adenocarcinoma and squamous cell carcinoma (78.4 vs 66.7%,P>0.05),and LRP expression correlated with lymph node metastasis, pathologic classification,and clinical staging(P<0.05). Conclusions HER-2 and LRP proteins are expressed to different degrees in non-small cell lung cancer.Assaying for both may be valuable for designing chemotherapy and predicting prognosis in non-small cell lung cancer.关键词
肺肿瘤/非小细胞肺癌/HER-2/LRP/基因表达/免疫组织化学法/预后Key words
Lung neoplasms/non-small cell lung cancer/HER-2/LRP/Gene expression/Immunohistochemistry/Prognosis分类
医药卫生引用本文复制引用
侯慧,高爽,任秋华,肖明明,景士兵..HER-2及LRP在非小细胞肺癌中的表达及临床意义[J].中国癌症防治杂志,2013,(4):315-319,5.
