中国癌症防治杂志Issue(4)：324-327,4.DOI:10.3969/j.issn.1674-5671.2013.04.09
潜在可切除胃癌新辅助化疗的临床疗效观察
Therapeutic efficacy of neoadjuvant chemotherapy for potentially resectable gastric cancer
摘要
Abstract
Objective To evaluate the efficacy and toxicity of neoadjuvant chemotherapy in patients with potentially resectable gastric cancer. Methods A total of 31 patients with potentially advanced gastric cancer were given 2-4 cycles of modified DCF combination therapy involving tegafur,cisplatinum,and docetaxel every three weeks. Clinical efficacy and toxicity were evaluated after every two cycles of chemotherapy. Results Of the 31 patients,1 responded completely,15 responded partially,10 showed stable disease and 5 progressive disease.The most frequent toxic effects associated with neoadjuvant treatment were myelosuppression,nausea and vomiting, and mild hepatic dysfunction. However,these effects were relieved after symptomatic treatment.In addition to chemotherapy,14 patients were treated surgically using R0 resection;4,R1 resection;2,R2 resection.No mortality was associated with the surgeries. Conclu-sions Neoadjuvant chemotherapy appears safe and effective in patients with potentially resectable gastric cancer. It can result in tumor downstaging,which increases the possibility of surgical resection.关键词
胃肿瘤/新辅助化疗/改良DCF方案/临床疗效Key words
Gastric neoplasms/Neoadjavant chemotherapy/Modified DCF regimen/Clinical effects分类
医药卫生引用本文复制引用
杨熙华,金钦文,王力,陈建思..潜在可切除胃癌新辅助化疗的临床疗效观察[J].中国癌症防治杂志,2013,(4):324-327,4.基金项目
广西医疗卫生重点科研基金资助项目 （）
