中国癌症防治杂志Issue(4)：328-332,5.DOI:10.3969/j.issn.1674-5671.2013.04.10
检测淋巴结中ERCC1蛋白指导非小细胞肺癌的个体化治疗
Detection of ERCC1 protein in lymph nodes for guiding individualized therapy in advanced non-small cell lung cancer
朱建荣 1万小蔹 1崔小川 1郁震1
作者信息
- 1. 214023 江苏无锡 南京医科大学附属无锡市人民医院呼吸科
- 折叠
摘要
Abstract
Objective To detect expression of excision repair cross-complementation group 1(ERCC1)protein in metastatic lymph nodes of patients with advanced non-small cell lung cancer (NSCLC),and investigate whether the expression can be useful for individualizing therapy. Methods A total of 96 patients with pathologically proven NSCLC involving lymph node metastasis were randomized between one group receiving standard treatment group(n=38),which was first-line platinum-based chemotherapy;and another group receiving individualized treatment(n=58),based on ERCC1 protein detection.Treatment effectiveness and Kaplan-Meier survival curves were compared between the two groups. Results ERCC1 protein was expressed in the metastatic lymph nodes of 51.7% of 58 cases.The response rate was significantly higher in the individualized treatment group(58.6%)than in the standard treatment group (34.2%,P=0.019),as was median overall survival (9 vs 7 months,P=0.039). Conclusions Individualized therapy based on ERCC1 protein detection in metastatic lymph nodes was associated with greater curative effect and survival than was standard therapy.关键词
肺肿瘤/非小细胞肺癌/核苷酸切除修复交叉互补基因1/个体化治疗Key words
Lung neoplasms/Non-small cell lung cancer/Excision repair cross-complementation group 1/Individualized therapy分类
医药卫生引用本文复制引用
朱建荣,万小蔹,崔小川,郁震..检测淋巴结中ERCC1蛋白指导非小细胞肺癌的个体化治疗[J].中国癌症防治杂志,2013,(4):328-332,5.
