中国癌症防治杂志Issue(4)：333-335,336,4.DOI:10.3969/j.issn.1674-5671.2013.04.11
早期三阴性乳腺癌与非三阴性乳腺癌VEGF和MVD表达的比较
Analysis of VEGF and MVD expression in primary triple-negative breast cancer and non-triple-negative breast cancer
摘要
Abstract
Objective To explore the expression of vascular endothelial growth factor(VEGF)and microvessel density(MVD)in pri-mary triple-negative breast cancer and non-triple-negative breast cancer. Methods Tissue samples from 21 patients with primary triple-negative breast cancer and 68 with primary non-triple-negative breast cancer who underwent radical surgery in our hospital be-tween January and December 2007 were examined by immunohistochemistry to detect VEGF expression and MVD (evaluated by CD34).Possible correlations of breast cancer type with VEGF expression or MVD were explored,as were correlations between VEGF expression and MVD. Results VEGF expression was significantly higher in triple-negative breast cancer(71.43%)than in non-triple-negative breast cancer(25.00%,P<0.001),but MVD was similar between the two types(P=0.105). Conclusions VEGF expression correlates with tumor angiogenesis and progression in triple-negative breast cancer,and this correlation deserves further study.关键词
乳腺肿瘤/三阴性乳腺癌/血管生成/血管内皮生长因子/微血管密度Key words
Breast neoplasms/Triple-negative breast cancer/Angiogenesis/Vascular endothelial growth factor/Microvessel density分类
医药卫生引用本文复制引用
孙洁,岑洪,谭晓虹..早期三阴性乳腺癌与非三阴性乳腺癌VEGF和MVD表达的比较[J].中国癌症防治杂志,2013,(4):333-335,336,4.基金项目
广西自然科学基金资助项目 （）
